Document Detail

Development of a dialyzer with enhanced internal filtration to increase the clearance of low molecular weight proteins.
MedLine Citation:
PMID:  15558337     Owner:  NLM     Status:  MEDLINE    
Accumulated low molecular weight proteins in hemodialysis patients require a high-flux dialyzer. There have been several methods proposed for enhancing internal filtration, including narrowing the inside diameter of the hollow fibers, lengthening the fibers, and increasing the fiber density ratio. We tried to enhance the internal filtration by increasing the pressure drop in the dialysate compartment through increasing the fiber density ratio. If the fiber density ratio is too high, however, an irregular dialysate path may result, thus decreasing dialysis performance. Therefore, we took note of the shape of the inner housing and added a short taper structure, which improved the dialysate path dramatically. Consequently, we developed an internal filtration-enhanced dialyzer (APS-Prototype) to improve dialysis performance. The internal filtration rate in water (measured by Doppler ultrasound) was 13.2 l/session for the APS-Prototype and 5.3 l/session for the APS-15E. The amount of alpha1-microglobulin (alpha1-MG) in bovine plasma was 0.34 g for the APS-Prototype and 0.11 g for the APS-15E. In addition, the amount of alpha1-MG in vivo was 29.0% +/- 5.8% for the APS-Prototype, significantly higher than that for the APS-15E (13.6% +/- 1.9%). The desirable loss of albumin is 2-4 g in hemodiafiltration, and it was 3.92 +/- 1.03 g for the APS-Prototype. The prototype showed excellent solute removal performance with no clinical or engineering problems.
Takayasu Fujimura; Yukihiko Uchi; Makoto Fukuda; Miwa Miyazaki; Satoshi Uezumi; Tatsuo Hiyoshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  7     ISSN:  1434-7229     ISO Abbreviation:  J Artif Organs     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Analysis and Simulation Center, Corporate Research and Development Administration, Asahi KASEI Corporation, 2-1 Samejima, Fuji, Shizuoka 416-8501, Japan.
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MeSH Terms
Alpha-Globulins / analysis
Materials Testing
Middle Aged
Regional Blood Flow
Ultrasonography, Doppler
Reg. No./Substance:
0/Alpha-Globulins; 0/alpha-1-microglobulin

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