| Development of diabetes mellitus in living pancreas donors and recipients. | |
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MedLine Citation:
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PMID: 21790295 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Previously, recurrence of insulin-dependent diabetes mellitus after pancreas transplants was only sporadically reported. Newer data, however, indicate recurrence rates as high as 5%. After identical-twin pancreas transplants, diabetes recurs in the absence of immunosuppressive therapy - strong evidence that it is an autoimmune disease. After deceased donor pancreas transplants, immunologic markers (autoantibodies, autoreactive T cells) herald recurrence. Selective destruction of β cells, still relatively uncommon, is not restricted to MHC compatibility. The development of diabetes in living pancreas donors is rare; it can be largely avoided by meticulous metabolic evaluation before donation and prevention of obesity after donation. |
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Authors:
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Rainer Wg Gruessner; Alberto Pugliese; Helena K Reijonen; Stephan Gruessner; Tun Jie; Chirag Desai; David Er Sutherland; George W Burke Iii |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 7 ISSN: 1744-8409 ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 543-51 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Arizona, Tucson, AZ 85724, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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