| Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone. | |
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MedLine Citation:
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PMID: 3308166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) has been shown in previous uncontrolled studies to be a limiting factor to long-term survival in patients undergoing cardiac transplantation and who were taking conventional immunosuppressive agents. To study the development of CAD after cardiac transplantation in patients taking the newer immunosuppressive agent cyclosporine, we prospectively performed yearly coronary arteriography on all eligible transplantation patients (first year, 57 patients; second year, 30 patients; third year, 14 patients). The prevalence of CAD by life table analysis was 18% at 1 year, 27% at 2 years, and 44% at 3 years. The occurrence of two or more major rejection episodes was associated (p less than .005) with the development of CAD. In two patients who died of CAD, coronary artery histology revealed subintimal inflammatory cellular infiltration in some lesions. These data demonstrate that the prevalence of CAD rises progressively over time and immunologic factors may be important in its development. |
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Authors:
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B F Uretsky; S Murali; P S Reddy; B Rabin; A Lee; B P Griffith; R L Hardesty; A Trento; H T Bahnson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 76 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1987 Oct |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 827-34 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Presbyterian University Hospital, Pittsburgh, PA 15213. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Angiography Coronary Disease / etiology*, pathology Coronary Vessels / pathology Cyclosporins / adverse effects*, therapeutic use Graft Rejection / drug effects Heart Transplantation* Humans Middle Aged Postoperative Complications* Prednisone / adverse effects*, therapeutic use Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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