Document Detail

Development of conical soluble phosphate glass fibers for directional tissue growth.
MedLine Citation:
PMID:  21273258     Owner:  NLM     Status:  Publisher    
One of the challenges of tissue engineering is the regulation of vascularization and innervations of the implant by the host. Here, we propose that using soluble phosphate glass (SPG) fibers, incorporated in dense collagen constructs will allow us to control the rate and direction of tissue ingrowth. The idea here was to generate channels with tailored direction using conical phosphate glass fibers. The changing surface area-to-mass ratio of conical fibers will make them to dissolve faster from their narrow ends opening up channels in that direction ahead of any ingrowing cells. In this study, we show that SPG fibers can be manipulated to produce conical shape fibers using graded dissolution. Our result shows that 40 µm fibers of composition ratio 0.5 (P(2)O(5)):0.25 (CaO):0.25 (Na(2)O) and dissolution time of 8-10 h have a mean reduction in fiber diameter of 8.85 ± 2.8 µm over 19.5 mm fiber length, i.e., a mean rate of 0.5 µm/mm (n = 20) change. These conically shaped fibers can also be manipulated and potentially used to promote uniaxial cell-tissue ingrowth for improved innervations and vascularization of tissue engineered constructs.
Tijna Alekseeva; Ensanya A Abou Neel; Jonathan C Knowles; Robert A Brown
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-27
Journal Detail:
Title:  Journal of biomaterials applications     Volume:  -     ISSN:  1530-8022     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813912     Medline TA:  J Biomater Appl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Tissue Repair and Engineering Centre, Institute of Orthopaedics, University College London, Stanmore Campus, London HA7 4LP, UK.
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