Document Detail

Development of a compliant surgical adhesive derived from novel fluorinated hexamethylene diisocyanate.
MedLine Citation:
PMID:  2557069     Owner:  NLM     Status:  MEDLINE    
We have recently developed a novel compliant surgical adhesive, based on urethane chemistry, that imparts excellent in vivo performance, except for a potential carcinogenic problem associated with aromatic diisocyanates. In this article, a chronic histopathologic study was conducted by implantation of adhesives in subcutaneous and hepatic tissues for up to 20 months. Neither carcinogenic episodes nor tissue abnormalities were found. Based on the structure-carcinogenic potential relationship of diisocyanates, fluorinated hexamethylene diisocyanate (HMDI) was found to be noncarcinogenic, despite its high nucleophilic reactivity. The fluorinated HMDI based adhesive was defined as the most reliable adhesive, with best in vivo performance, including ensured nontoxicity.
T Matsuda; N Nakajima; T Itoh; T Takakura
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  ASAIO transactions / American Society for Artificial Internal Organs     Volume:  35     ISSN:  0889-7190     ISO Abbreviation:  ASAIO Trans     Publication Date:    1989 Jul-Sep
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8611947     Medline TA:  ASAIO Trans     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-3     Citation Subset:  IM    
Department of Bioengineering, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Carcinogenicity Tests
Connective Tissue / drug effects
Cyanates / toxicity*
Liver / drug effects
Rats, Inbred Strains
Structure-Activity Relationship
Tissue Adhesives*
Toluene 2,4-Diisocyanate / toxicity
Reg. No./Substance:
0/Cyanates; 0/Tissue Adhesives; 584-84-9/Toluene 2,4-Diisocyanate; 822-06-0/1,6-hexamethylene diisocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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