Document Detail


Development of a completely autologous valved conduit with the sinus of Valsalva using in-body tissue architecture technology: a pilot study in pulmonary valve replacement in a beagle model.
MedLine Citation:
PMID:  20837900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We developed autologous prosthetic implants by simple and safe in-body tissue architecture technology. We present the first report on the development of autologous valved conduit with the sinus of Valsalva (BIOVALVE) by using this unique technology and its subsequent implantation in the pulmonary valves in a beagle model. METHODS AND RESULTS: A mold of BIOVALVE organization was assembled using 2 types of specially designed silicone rods with a small aperture in a trileaflet shape between them. The concave rods had 3 projections that resembled the protrusions of the sinus of Valsalva. The molds were placed in the dorsal subcutaneous spaces of beagle dogs for 4 weeks. The molds were covered with autologous connective tissues. BIOVALVEs with 3 leaflets in the inner side of the conduit with the sinus of Valsalva were obtained after removing the molds. These valves had adequate burst strength, similar to that of native valves. Tight valvular coaptation and sufficient open orifice area were observed in vitro. These BIOVALVEs were implanted to the main pulmonary arteries as allogenic conduit valves (n=3). Postoperative echocardiography demonstrated smooth movement of the leaflets with trivial regurgitation. Histological examination of specimens obtained at 84 days showed that the surface of the leaflet was covered by endothelial cells and neointima, including an elastin fiber network, and was formed at the anastomosis sides on the luminal surface of the conduit. CONCLUSIONS: We developed the first completely autologous BIOVALVE and successfully implanted these BIOVALVEs in a beagle model in a pilot study.
Authors:
Masashi Yamanami; Yuki Yahata; Masami Uechi; Megumi Fujiwara; Hatsue Ishibashi-Ueda; Keiichi Kanda; Taiji Watanabe; Tsutomu Tajikawa; Kenkichi Ohba; Hitoshi Yaku; Yasuhide Nakayama
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  122     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S100-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bioprosthesis*
Dogs
Echocardiography / methods
Humans
Models, Biological*
Pulmonary Artery / surgery*,  ultrasonography
Sinus of Valsalva / surgery*,  ultrasonography
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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