Document Detail

Development of a compensation algorithm for accurate depth localization in diffuse optical tomography.
MedLine Citation:
PMID:  20125744     Owner:  NLM     Status:  MEDLINE    
Diffuse optical tomography endures poor depth localization, since its sensitivity decreases severely with increased depth. In this study, we demonstrate a depth compensation algorithm (DCA), which optimally counterbalances the decay nature of light propagation in tissue so as to accurately localize absorbers in deep tissue. The novelty of DCA is to directly modify the sensitivity matrix, rather than the penalty term of regularization. DCA is based on maximum singular values (MSVs) of layered measurement sensitivities; these MSVs are inversely utilized to create a balancing weight matrix for compensating the measurement sensitivity in increased depth. Both computer simulations and laboratory experiments were performed to validate DCA. These results demonstrate that one (or two) 3-cm-deep absorber(s) can be accurately located in both lateral plane and depth within the laboratorial position errors.
Haijing Niu; Fenghua Tian; Zi-Jing Lin; Hanli Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Optics letters     Volume:  35     ISSN:  1539-4794     ISO Abbreviation:  Opt Lett     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-31     Citation Subset:  IM    
Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, University of Texas at Arlington, Arlington, Texas 76019, USA
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MeSH Terms
Brain / pathology*
Computer Simulation
Diagnostic Imaging / methods
Image Processing, Computer-Assisted / methods
Optics and Photonics
Phantoms, Imaging
Reproducibility of Results
Tomography, Optical / methods*
Grant Support
4R33NS052850-03/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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