Document Detail


Development and comparative evaluation of a multiple-antigen RAST as a screening test for inhalant allergy.
MedLine Citation:
PMID:  6608549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a modified in vitro test for IgE antibodies, the multi-RAST, to detect antibodies of different allergen specificities simultaneously in a single tube. The multi-RAST is as sensitive for detecting low concentrations of individual IgE antibodies as the discrete RAST. We also evaluated the multi-RAST as a screening test for respiratory allergy to inhalant allergens in children by comparing the results of the multi-RAST performed by use of a mixture of SRP, TGP, and DF allergen-immunosorbents with the results of skin tests, discrete RAST tests for the same allergens, serum total IgE concentrations, and nasal smears for eosinophils in 100 children referred for allergic-disease evaluation. The results of the multi-RAST were more sensitive, specific, and efficient than the results of tests for serum IgE concentration and nasal eosinophils in establishing the diagnosis of inhalant allergy; the multi-RAST was the only diagnostic test that yielded results that were significantly associated with the clinician's impression of allergy. We conclude that the multi-RAST is a useful and cost-effective screening test for inhalant allergy in children.
Authors:
D R Ownby; J A Anderson; G L Jacobs; H A Homburger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  73     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-72     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Anti-Idiotypic / analysis
Antibody Specificity
Child
Child, Preschool
Evaluation Studies as Topic
Humans
Immunoglobulin E / analysis,  immunology
Infant
Mites / immunology
Pollen / immunology
Radioallergosorbent Test / methods*
Radioimmunoassay / methods*
Respiratory Hypersensitivity / diagnosis*
Skin Tests
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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