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Development of a compact terahertz time-domain spectrometer for the measurement of the optical properties of biological tissues.
MedLine Citation:
PMID:  21529096     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Terahertz spectrometers and imaging systems are currently being evaluated as biomedical tools for skin burn assessment. These systems show promise, but due to their size and weight, they have restricted portability, and are impractical for military and battlefield settings where space is limited. In this study, we developed and tested the performance of a compact, light, and portable THz time-domain spectroscopy (THz-TDS) device. Optical properties were collected with this system from 0.1 to 1.6 THz for water, ethanol, and several ex vivo porcine tissues (muscle, adipose, skin). For all samples tested, we found that the index of refraction (n) decreases with frequency, while the absorption coefficient (μ(a)) increases with frequency. Muscle, adipose, and frozen∕thawed skin samples exhibited comparable n values ranging between 2.5 and 2.0, whereas the n values for freshly harvested skin were roughly 40% lower. Additionally, we found that the freshly harvested samples exhibited higher μ(a) values than the frozen∕thawed skin samples. Overall, for all liquids and tissues tested, we found that our system measured optical property values that were consistent with those reported in the literature. These results suggest that our compact THz spectrometer performed comparable to its larger counterparts, and therefore may be a useful and practical tool for skin health assessment.
Authors:
Gerald J Wilmink; Bennett L Ibey; Thomas Tongue; Brian Schulkin; Norman Laman; Xomalin G Peralta; Caleb C Roth; Cesario Z Cerna; Benjamin D Rivest; Jessica E Grundt; William P Roach
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  16     ISSN:  1560-2281     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  -    
Other Details:
Languages:  ENG     Pagination:  047006     Citation Subset:  -    
Affiliation:
Air Force Research Laboratory, 711 Human Performance Wing, Human Effectiveness Directorate, Radio Frequency Radiation Branch, 8262 Hawks Road, Brooks City-Base, Texas 78235National Academy of Sciences National Research Council Research Associateship, 500 Fifth Street, N.W., Washington, D.C. 20001Zomega Terahertz Corporation, 2121 Sixth Avenue, Troy, New York 12180University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249General Dynamics Advanced Information Services, 8262 Hawks Road, Brooks City-Base, Texas 78235.
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