Document Detail

Development of a citric acid aerosol as a smoking cessation aid.
MedLine Citation:
PMID:  2189719     Owner:  NLM     Status:  MEDLINE    
The satisfaction derived from smoking depends not only on the pharmacological effects of nicotine but also the sensory stimulation from smoke inhalation, particularly the tracheal 'scratch'. In a previous study, we found that a citric acid aerosol produces a tracheal 'scratch' and provides some of the same satisfaction as cigarette smoke. In the present study, we evaluated a new pocket-sized device for delivering a citric acid aerosol and examined some of the important variables for providing a satisfying substitute for cigarettes. In the first experiment, volunteers who smoked at least 10 cigarettes per day compared a citric acid aerosol (either alone or with flavor additives) to a cigarette and a placebo. The addition of cigarette smoke flavor was found to best enhance the satisfaction provided by the citric acid aerosol. In the second experiment, smokers were given compact citric acid inhalers to use throughout 8 h of cigarette deprivation. The degree of satisfaction was highly correlated with the intensity of throat sensation provided by the aerosol. This citric acid aerosol inhaler may provide a useful tool for smokers while trying to quit smoking.
E D Levin; J E Rose; F Behm
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  25     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Nicotine Research Laboratory, VA Medical Center, Durham, NC 27705.
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MeSH Terms
Analysis of Variance
Citrates / administration & dosage*,  therapeutic use
Citric Acid
Consumer Satisfaction*
Evaluation Studies as Topic
Flavoring Agents / pharmacology
Nebulizers and Vaporizers*
Nicotine / pharmacology
Randomized Controlled Trials as Topic
Respiratory System / drug effects
Sensation / drug effects*,  physiology
Smoking / prevention & control*
Trachea / drug effects*,  physiology
Reg. No./Substance:
0/Aerosols; 0/Citrates; 0/Flavoring Agents; 54-11-5/Nicotine; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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