Document Detail

Development and characterization of pantothenic acid transport in brain.
MedLine Citation:
PMID:  3734794     Owner:  NLM     Status:  MEDLINE    
In vitro, the transport of [3H]pantothenic acid into and from rabbit brain slices was studied. In newborn rabbits and throughout development, forebrain and cerebellar slices were able to accumulate and phosphorylate [3H]pantothenic acid comparably to slices from adults. The accumulation and phosphorylation of [3H]pantothenic acid by adult forebrain slices were not decreased by substitution of LiCl for NaCl in the artificial CSF or by addition of short-chain fuels (e.g., 5 mM pyruvate or acetoacetate) to the medium. However, probenecid and ouabain (both 1 mM) and medium-chain fatty acids (e.g., 0.1 mM octanoate, nonanoate, and decanoate) profoundly inhibited [3H]pantothenic acid accumulation by forebrain slices but not intracellular phosphorylation and conversion to [3H]CoA. There in vitro results suggest that brain slices accumulate pantothenic acid by a saturable system (probably facilitated diffusion) that is sensitive to inhibition by probenecid and medium-chain fatty acids.
R Spector
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  47     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-8     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / metabolism
Biological Transport / drug effects
Brain / growth & development*,  metabolism
Cerebellum / metabolism
Choroid Plexus / metabolism
Diencephalon / metabolism
Fatty Acids / pharmacology
Ouabain / pharmacology
Pantothenic Acid / metabolism*
Probenecid / pharmacology
Telencephalon / metabolism
Reg. No./Substance:
0/Fatty Acids; 57-66-9/Probenecid; 630-60-4/Ouabain; 79-83-4/Pantothenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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