| Development and characterization of oleic acid vesicles for the topical delivery of fluconazole. | |
| | |
MedLine Citation:
|
PMID: 20235758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fatty acids have been widely used as adjuvant, vehicles in drug delivery viz penetration enhancers in topical delivery and in polymeric micelles to provide sustained release. However, the present investigation aims at exploring the potential of fatty acid vesicles for the topical delivery of fluconazole. Vesicles were prepared by film hydration method using oleic acid as a fatty acid principal component. Developed vesicles were characterized for size, size distribution, shape, in vitro release, pH dependent and storage stability, skin irritation study, and ex-vivo skin permeation. Penetration behavior of vesicles was further evaluated and elucidated using confocal microscopic study. Optical microscopy and TEM studies confirmed vesicular dispersion of fatty acid. The vesicles possessed higher entrapment efficiency (44.11%) with optimum vesicle size and homogeneity in regard to size distribution (PDI = 0.234 +/- 0.016) at 7:3 oleic acid-to-fluconazole ratio. In vitro drug release study suggested sustained release of drug from the vesicles. The release pattern followed Higuchian kinetics. The vesicles were fairly stable at refrigerated conditions. Ex-vivo skin permeation and confocal microscopic studies suggested that oleic acid vesicles penetrate the stratum corneum and retain the drug accumulated in the epidermal part of the skin. On the basis of sustained release behavior and skin retention it can be inferred that oleic acid vesicles can serve as a potential carrier for the topical localized delivery of bioactives. |
| | |
Authors:
|
Foziyah Zakir; Bhuvaneshwar Vaidya; Amit K Goyal; Basant Malik; Suresh P Vyas |
Related Documents
:
|
21847018 - Grasshopper oral secretions increase salicylic acid and abscic acid levels in wounded l... 20644558 - Trans fatty acids and weight gain. 445848 - Mechanisms of interference of nonesterified fatty acids in radioimmunoassays of steroids. 6421238 - Biosynthesis of medium chain fatty acids in drosophila melanogaster. 8724878 - Lipid and fatty acid contents in red tides from tropical fish ponds of the coastal wate... 20592728 - Co-option of the hormone-signalling module dafachronic acid-daf-12 in nematode evolution. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Drug delivery Volume: 17 ISSN: 1521-0464 ISO Abbreviation: Drug Deliv Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-19 Completed Date: 2010-11-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9417471 Medline TA: Drug Deliv Country: England |
Other Details:
|
Languages: eng Pagination: 238-48 Citation Subset: IM |
Affiliation:
|
Nanomedicine Research Center, ISF College of Pharmacy, Moga (Punjab), India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Animals Drug Delivery Systems / methods* Fluconazole / administration & dosage*, chemistry*, pharmacokinetics Guinea Pigs Male Oleic Acid / administration & dosage*, chemical synthesis*, pharmacokinetics Skin Absorption / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
112-80-1/Oleic Acid; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meaning in life in patients with amyotrophic lateral sclerosis.
Next Document: Understanding the role of communication in maintaining and forming friendships following traumatic b...