Document Detail


Development of celiac disease-associated antibodies in offspring of parents with type I diabetes.
MedLine Citation:
PMID:  10990078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS/HYPOTHESIS: The aim of this study was to determine the frequency and temporal development of antibodies related to celiac disease in offspring of parents with Type I (insulin-dependent) diabetes mellitus. METHODS: Sera from 913 offspring of parents with Type I diabetes prospectively followed from birth to the age of 8 years were tested for IgG-transglutaminase antibodies (IgG-tTGCAs), endomysial IgA antibodies (EMA) and gliadin antibodies. RESULTS: We found tTGCAs in 32 (3.5%) of the 913 relatives. Prevalence was related to age and reached 6.5% at age 8 years. Endomysial IgA antibodies were detected in 44% of the relatives with tTGCAs and 0.6% of tTGCA negative relatives and were also most prevalent (5 %) in those aged 8 years. Both tTGCAs and EMAs were more frequent in relatives with the HLA DRB1*03 DQA1*0501 DQB1*02 haplotype (7.1% and 7.2%, respectively; p < 0.005). Antigliadin antibodies were common in both tTGCA positive (42%) and negative (23%) relatives, did not show a relation with age and were less prevalent in relatives with HLA DR3 (p < 0.05). There was no association between the presence of antibodies associated with celiac disease and islet autoantibodies in these relatives. Of the relatives 15 (1.6%) had tTGCAs plus EMAs. In two of these, anti-gliadin antibodies were detected before the detection of tTGCAs and EMAs at the age of 9 months whereas none of the remainder had any antibodies associated with celiac disease before age 2 years. In three there were no detectable antigliadin antibodies in any of the samples tested. Celiac disease without clinical symptoms was diagnosed in 9 of 12 by intestinal biopsy. CONCLUSION/INTERPRETATION. A statistically significant proportion of relatives of patients with Type I diabetes have celiac disease-associated autoimmunity and the silent form of celiac disease early in life. These relatives should, therefore, be considered for celiac antibody screening.
Authors:
M Hummel; E Bonifacio; M Stern; J Dittler; A Schimmel; A G Ziegler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetologia     Volume:  43     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-05     Completed Date:  2001-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1005-11     Citation Subset:  IM    
Affiliation:
Diabetes Research Institute and 3rd Medical Department, Academic Teaching Hospital München-Schwabing, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Autoantibodies / blood*
Celiac Disease / blood,  genetics,  immunology*
Cohort Studies
Diabetes Mellitus, Type 1 / genetics*
Gliadin / immunology*
HLA-D Antigens / blood
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Infant, Newborn
Longitudinal Studies
Nuclear Family
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/HLA-D Antigens; 0/Immunoglobulin A; 0/Immunoglobulin G; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases

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