| Development of canine nephrotic syndrome model. | |
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MedLine Citation:
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PMID: 15031545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To develop an experimental animal model for immune-mediated glomerulonephritis and nephrotic syndrome, nine healthy dogs were sensitized by intravenous injection with 1 microg of endotoxin and 5 mg of native bovine serum albumin. After 1 week, 120 mg of cationized bovine serum albumin was injected intravenously 5 times a week. Among nine dogs, five dogs were confirmed as having developed glomerulonephritis and nephrotic syndrome by increase of urine protein-to-creatinine ratio (>1.0), hypoalbuminemia (<1.5 g/dl), hypercholesterolemia (>240 mg/dl), and edema. This model should be useful for studying immune-mediated glomerulonephritis and nephrotic syndrome. |
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Authors:
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Eun-Wha Choi; Chang-Woo Lee |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 66 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-19 Completed Date: 2004-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University, Kwanak-gu, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Creatine / urine Disease Models, Animal* Dogs Female Glomerulonephritis / chemically induced* Immunohistochemistry Kidney / pathology Male Nephrotic Syndrome / chemically induced* Serum Albumin, Bovine |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin, Bovine; 57-00-1/Creatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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