Document Detail


Development of a buccal bioadhesive nicotine tablet formulation for smoking cessation.
MedLine Citation:
PMID:  15158980     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioadhesive buccal tablet formulations for delivery of nicotine into the oral cavity were developed. Carbomer (Carbopol)974P NF) (CP) and alginic acid sodium salt (NaAlg) were used as bioadhesive polymers in combination with hydroxypropyl methylcellulose (HPMC) at different ratios. Magnesium carbonate was incorporated into the formulations as a pH increasing agent. In vitro release and bioadhesion studies were performed on the developed tablets. In the formulations containing CP:HPMC, the NHT released increased with the increasing HPMC concentration whereas a decrease was observed with increasing HPMC concentration in formulations containing NaAlg:HPMC. The bioadhesive properties of the tablets containing NaAlg:HPMC was not affected by the concentration of the NaAlg (P>0.05) but increased significantly with the increasing CP concentration (P>0.05). A decrease in pH of the dissolution medium to acidic values was avoided by incorporation of magnesium hydroxide into the formulations. The developed formulations released NHT for 8h period, and remained intact except for the formulation containing CP:HPMC at 20:80 ratio.
Authors:
G Ikinci; S Senel; C G Wilson; M Sumnu
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  277     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adhesives
Administration, Buccal
Animals
Cattle
Chemistry, Pharmaceutical
Diffusion Chambers, Culture / methods
Mouth Mucosa / drug effects,  metabolism*
Nicotine / administration & dosage,  pharmacokinetics*
Smoking Cessation / methods*
Tablets
Chemical
Reg. No./Substance:
0/Adhesives; 0/Tablets; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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