| Development of bronchoconstriction after administration of muscle relaxants in rabbits with normal or hyperreactive airways. | |
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MedLine Citation:
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PMID: 16790635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuromuscular blocking drugs can induce intraoperative bronchospasm. We characterized the magnitude and the temporal profile of the constriction in normal or in hyperresponsive airways after injections of neuromuscular blocking drugs. Respiratory system impedance (Zrs) was measured continuously over a 90-s apneic period in naïve and rabbits sensitized to allergens by ovalbumin. Fifteen s after the start of Zrs recordings, succinylcholine, mivacurium, or pipecuronium was administered in random order. Zrs was then also recorded during the administration of increasing doses of exogenous histamine. To monitor the changes in the airway mechanics during these maneuvers, Zrs was averaged for 2-s time windows, and the airway resistance (Raw) was determined by model fitting. The increases in Raw were significantly larger in the sensitized rabbits than in the naïve animals. The largest increases in Raw and the maximum rate of change in Raw were obtained for succinylcholine (146% +/- 29% and 0.80 +/- 0.12 cm H2O/L, respectively) and mivacurium (80% +/- 25% and 0.71 +/- 0.13 cm H2O/L) and the smallest were obtained for pipecuronium (40% +/- 12% and 0.41 +/- 0.04 cm H2O/L). Allergic sensitization leads to severe and rapidly developing bronchospasm after administrations of mivacurium or succinylcholine. These deleterious side effects should be considered when succinylcholine or mivacurium is administered in the presence of bronchial hyperreactivity. |
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Authors:
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Ferenc Peták; Zoltán Hantos; Agnes Adamicza; Hristifor Gálity; Walid Habre |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 103 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-22 Completed Date: 2006-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 103-9, table of contents Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Informatics, University of Szeged, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Animals Bronchial Hyperreactivity / physiopathology* Bronchoconstriction / drug effects* Histamine / pharmacology Isoquinolines / pharmacology Neuromuscular Blocking Agents / pharmacology* Pipecuronium / pharmacology Rabbits Respiratory Hypersensitivity / physiopathology Succinylcholine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 0/Neuromuscular Blocking Agents; 106791-40-6/mivacurium; 306-40-1/Succinylcholine; 51-45-6/Histamine; 68399-58-6/Pipecuronium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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