Document Detail

Development of bronchoconstriction after administration of muscle relaxants in rabbits with normal or hyperreactive airways.
MedLine Citation:
PMID:  16790635     Owner:  NLM     Status:  MEDLINE    
Neuromuscular blocking drugs can induce intraoperative bronchospasm. We characterized the magnitude and the temporal profile of the constriction in normal or in hyperresponsive airways after injections of neuromuscular blocking drugs. Respiratory system impedance (Zrs) was measured continuously over a 90-s apneic period in naïve and rabbits sensitized to allergens by ovalbumin. Fifteen s after the start of Zrs recordings, succinylcholine, mivacurium, or pipecuronium was administered in random order. Zrs was then also recorded during the administration of increasing doses of exogenous histamine. To monitor the changes in the airway mechanics during these maneuvers, Zrs was averaged for 2-s time windows, and the airway resistance (Raw) was determined by model fitting. The increases in Raw were significantly larger in the sensitized rabbits than in the naïve animals. The largest increases in Raw and the maximum rate of change in Raw were obtained for succinylcholine (146% +/- 29% and 0.80 +/- 0.12 cm H2O/L, respectively) and mivacurium (80% +/- 25% and 0.71 +/- 0.13 cm H2O/L) and the smallest were obtained for pipecuronium (40% +/- 12% and 0.41 +/- 0.04 cm H2O/L). Allergic sensitization leads to severe and rapidly developing bronchospasm after administrations of mivacurium or succinylcholine. These deleterious side effects should be considered when succinylcholine or mivacurium is administered in the presence of bronchial hyperreactivity.
Ferenc Peták; Zoltán Hantos; Agnes Adamicza; Hristifor Gálity; Walid Habre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-22     Completed Date:  2006-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9, table of contents     Citation Subset:  AIM; IM    
Department of Medical Informatics, University of Szeged, Hungary.
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MeSH Terms
Airway Resistance
Bronchial Hyperreactivity / physiopathology*
Bronchoconstriction / drug effects*
Histamine / pharmacology
Isoquinolines / pharmacology
Neuromuscular Blocking Agents / pharmacology*
Pipecuronium / pharmacology
Respiratory Hypersensitivity / physiopathology
Succinylcholine / pharmacology
Reg. No./Substance:
0/Isoquinolines; 0/Neuromuscular Blocking Agents; 106791-40-6/mivacurium; 306-40-1/Succinylcholine; 51-45-6/Histamine; 68399-58-6/Pipecuronium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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