| Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F. | |
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MedLine Citation:
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PMID: 7532114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From the less polar fraction of Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla Seringe var. thunbergii Makino, Eight antiallergic and antimicrobial principles were isolated together with several known compounds. Among the newly isolated bioactive constituents, the chemical structures of thunberginols A, B, and F have been determined on the basis of chemical and physicochemical evidence. Thunberginols A, B, and F were found to exhibit more potent antiallergic activity than phyllodulcin, hydrangenol, disodium cromoglycate (DSCG), and tranilast. In addition, these thunberginols showed antimicrobial activity against oral bacteria. |
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Authors:
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M Yoshikawa; E Harada; Y Naitoh; K Inoue; H Matsuda; H Shimoda; J Yamahara; N Murakami |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 42 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-03-21 Completed Date: 1995-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 2225-30 Citation Subset: IM |
Affiliation:
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Kyoto Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology* Benzofurans / isolation & purification, pharmacology* Coumarins / isolation & purification, pharmacology* Guinea Pigs Histamine Release / drug effects* Isocoumarins Magnetic Resonance Spectroscopy Male Microbial Sensitivity Tests Plant Extracts / analysis, pharmacology* Plant Leaves Plants, Medicinal / chemistry* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Benzofurans; 0/Coumarins; 0/Isocoumarins; 0/Plant Extracts; 147666-80-6/thunberginol A; 147666-81-7/thunberginol B; 147666-82-8/thunberginol F |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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