Document Detail

Development of bile secretory function in the neonatal guinea pig.
MedLine Citation:
PMID:  2076447     Owner:  NLM     Status:  MEDLINE    
Maturation of hepatic bile formation and lipid secretion were examined in neonatal guinea pigs in an attempt to explain the earlier observation that the neonate (15 days old) is less susceptible to lithocholate-induced cholestasis than the adult. Bile flow and bile acid secretion were lowest at 12 h postpartum and increased to attain a maximum at 15 days. Thereafter, values decreased to a level which was not significantly different from that at 3 days of age. Bile acid analysis indicated the presence of chenodeoxycholic acid, 7-ketolithocholic acid and ursodeoxycholic acid in bile at all ages. But, at 15 days ursodeoxycholic acid was a major contributor to total bile acid secretion. Phospholipid and cholesterol secretion increased between the 1st and the 3rd day of age but decreased markedly at 15 days. This indicated an uncoupling of biliary lipid secretion and endogenous bile acids which was related in part to the nature of the bile acids secreted. Serum bile acid levels were markedly increased at 15 days of age. This hypercholanemia may reflect a rapid expansion of the bile acid pool including an enhanced bile acid secretion which could explain in part the resistance to the lithocholate cholestasis by increasing the secretory capacity for the toxic bile acid.
B Tuchweber; N Ducruet; A Perea; I M Yousef; A M Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  58     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-22     Completed Date:  1991-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  279-90     Citation Subset:  IM    
Department of Nutrition, University of Montreal, Canada.
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MeSH Terms
Animals, Newborn
Bile / secretion*
Bile Acids and Salts / blood,  secretion*
Body Weight
Chenodeoxycholic Acid / metabolism
Cholesterol / secretion
Guinea Pigs
Liver / growth & development*,  ultrastructure
Organ Size
Organelles / ultrastructure
Phospholipids / secretion
Reg. No./Substance:
0/Bile Acids and Salts; 0/Phospholipids; 474-25-9/Chenodeoxycholic Acid; 57-88-5/Cholesterol

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