Document Detail


Development of autonomic dysfunction with intermittent hypoxia in a lean murine model.
MedLine Citation:
PMID:  23774144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intermittent hypoxia (IH) has been previously shown in a lean murine model to produce sustained hypertension and reverse the diurnal variation of blood glucose (BG). Concomitant glucose infusion attenuated the hypertension but exacerbated the BG fluctuations. In this study, cardiovascular variability analysis was employed to track the development of autonomic dysfunction in mice exposed to room air (IA) or IH, in combination with saline or glucose infusion. Baroreflex sensitivity was found to decrease in all animals, except in the control group. Low-frequency power of pulse interval spectrum, reflecting vagal activity, decreased more rapidly in glucose relative to saline while low-frequency power of blood pressure, reflecting sympathetic activity, decreased more slowly in IH relative to IA. Ultradian (≈ 12 h) rhythmicity was substantially suppressed in IH groups. These findings suggest that IH acted to increase sympathetic activity while glucose infusion led to reduced parasympathetic activity. The combination of IH and hyperglycemia leads to progressively adverse effects on autonomic control independent of obesity.
Authors:
P Chalacheva; J Thum; T Yokoe; C P O'Donnell; M C K Khoo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-06-14
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  188     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-29     Completed Date:  2014-02-27     Revised Date:  2014-08-18    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anoxia / complications*
Autonomic Nervous System Diseases / complications*
Baroreflex / physiology*
Blood Glucose / physiology
Blood Pressure / physiology*
Circadian Rhythm / physiology
Disease Models, Animal
Heart Rate / physiology*
Male
Mice
Spectrum Analysis
Time Factors
Grant Support
ID/Acronym/Agency:
EB001978/EB/NIBIB NIH HHS; HL077785/HL/NHLBI NIH HHS; HL090451/HL/NHLBI NIH HHS; P41 EB001978/EB/NIBIB NIH HHS; R01 HL077785/HL/NHLBI NIH HHS; R21 HL090451/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose
Comments/Corrections

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