Document Detail

Development of atrophy of the retinal pigment epithelium around disciform scars.
MedLine Citation:
PMID:  16547324     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Eyes with burnt out disciform scars secondary to age related macular degeneration (AMD) are regarded as visually stable. The aim of this study is to report the subsequent development of atrophy of the retinal pigment epithelium (RPE) around the scars and discuss the possible basis.
METHODS: 20 eyes from 18 patients were observed to develop atrophy around choroidal neovascularisation (CNV). A method of measuring expansion of the atrophy over time is described using the Topcon Imagenet 2000 system. An additional 10 clinicopathological examples were reviewed.
RESULTS: Clinically CNV became surrounded initially by a ring of pallor that progressed to an expanding band of atrophy of the RPE. It developed most rapidly in the first 3 years after CNV became quiescent but then continued to expand slowly to more than three times the size of the scar. Histopathological specimens showed large choroidal vessels entering the scars directly and a reduced number of small choroidal vessels beneath and around the scar
CONCLUSIONS: Disciform scars may become surrounded by an expanding band of atrophy of the RPE, postulated to result from remodelling of the choroidal circulation. The ongoing enlargement of the resulting scotoma may need to be considered when planning management and assessing treatment outcomes.
J Sarks; K Tang; M Killingsworth; J Arnold; S Sarks
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  90     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-04-13     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  442-6     Citation Subset:  IM    
Prince of Wales Medical Research Institute, Randwick, Sydney, NSW, Australia.
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MeSH Terms
Aged, 80 and over
Atrophy / etiology,  pathology
Choroidal Neovascularization / complications
Cicatrix / complications*,  pathology
Disease Progression
Fluorescein Angiography
Follow-Up Studies
Macular Degeneration / complications*
Middle Aged
Pigment Epithelium of Eye / pathology*
Comment In:
Br J Ophthalmol. 2006 Apr;90(4):398-9   [PMID:  16547309 ]
Br J Ophthalmol. 2006 Apr;90(4):396-7   [PMID:  16547308 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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