Document Detail

Development of the atrioventricular junctional area in the human heart.
MedLine Citation:
PMID:  11234695     Owner:  NLM     Status:  MEDLINE    
The structure of the heart has been the subject of many observations since the beginnings of medical research. The first information regarding the existence of the conduction system of the heart was described by Purkinje and regarding the a-v node by Tawara. From the history regarding this structure it seems that this special system, so relevant to today's invasive cardiologist, is not understood in full. With regards to the interventional electrophysiology on the basis of histological study we decided to evaluate in detail the morphology and the topography of the various portions of the a-v junction. In order to confirm this hypothesis we made observations on the autopsy material of 100 normal human hearts, both sexes from 16 weeks of foetal life to 105 years of age, in which no pathological changes or inborn faults were found. Sections were done containing the heart's septum, stained using Masson's method with Goldner's modification. This research proves that the atrioventricular junction is a stable structure occurring in all hearts, undergoing involutionary changes with age, in which two main parts can be differentiated: the node and the bundle. The morphology of the node is very complex, because it is composed of three zones: the prenodal, the perinodal and the main, differing in cell structure and position. The topography of the node is generally stable, as it lies in the interatrial septum and always above the septal leaflet of the tricuspid valve. The structure of the bundle, in contrast to the node, is more stable and consists of the following parts: the penetrating, the non-branching and the branching. Its topography is also stable, as it lies in the membranous septum, mainly below the septal cusp of the tricuspid valve.
D Kozłowski; M Grzybiak; A Owerczuk; M Kozłowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia morphologica     Volume:  60     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-07     Completed Date:  2001-03-29     Revised Date:  2006-06-23    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
2nd Department of Cardiac Diseases, Medical University, ul. Kieturakisa 1, 80-742 Gdańsk, Poland.
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MeSH Terms
Aged, 80 and over
Atrioventricular Node / anatomy & histology,  embryology*
Bundle of His / anatomy & histology,  embryology*
Child, Preschool
Fetus / embryology
Heart / anatomy & histology,  embryology
Infant, Newborn
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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