Document Detail

Development of arteries in embryonic chick bone marrow with special reference to the appearance of periarterial granulopoietic sheaths.
MedLine Citation:
PMID:  3189868     Owner:  NLM     Status:  MEDLINE    
Arterial development was studied in embryonic chick bone marrow starting on day 11 of incubation and continuing until day 18. Arteries first appear on day 11 as vessels with two components to their wall structure, namely a thin, complete endothelium and a nearly complete pericyte layer. With advancing age, three distinct layers--an endothelium, a complete muscularis, and adventitia--appear. Long, narrow endothelial cells form cellular junctions at their basal surfaces. Smooth muscle cells remain relatively undifferentiated and do not consist of more than three layers even in the largest arteries. The adventitia consists of a hypocellular zone containing fibroblasts and a collagenous extracellular matrix. Unmyelinated nerves are located at the peripheral margin of the adventitia. All of the larger arteries are surrounded by a sheath of heterophilic granulopoietic cells. These cells do not intrude into the adventitia, but basophilic or mast cells often do intrude. The stromal cells of the periarterial granulopoietic sheaths remain as either fibroblastic cells or as multilocular preadipocytes. They, unlike those stromal cells beyond the sheath, never become unilocular adipocytes. By day 18, granulopoiesis is restricted to the periarterial sheaths and to the endosteal regions of the marrow. These studies indicate that fibroblastic stromal cells and preadipocytes, but not fully developed adipocytes, support granulopoiesis in the chick marrow. The stromal cells in the periarterial sheaths either represent a subpopulation of cells that do not develop into adipocytes or represent cells whose development into adipocytes is locally inhibited.
J M Sorrell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  221     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-12-16     Completed Date:  1988-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  730-6     Citation Subset:  IM    
Department of Anatomy, School of Medicine, West Virginia University, Morgantown 26506.
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MeSH Terms
Arteries / cytology,  embryology,  innervation
Bone Marrow / blood supply*
Chick Embryo
Endothelium, Vascular / ultrastructure
Grant Support

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