Document Detail

Development of arrhythmias in the patient with congestive heart failure: pathophysiology, prevalence and prognosis.
MedLine Citation:
PMID:  3946204     Owner:  NLM     Status:  MEDLINE    
While the number of deaths from coronary artery and cerebrovascular disease is clearly decreasing in the U.S., the prevalence of congestive heart failure (CHF) seems to be increasing. Many studies have found that more than half of the CHF-related deaths are sudden, and presumably are due to ventricular arrhythmias. Knowledge of the pathophysiology of arrhythmias in the patient with CHF is limited, but left ventricular mechanical abnormalities, diuretic-induced hypokalemia, hypomagnesemia and inotropic therapy may play a role. The prevalence of couplets, multiformed ventricular premature complexes or both is very high, averaging 87% in 8 different studies. The prevalence of nonsustained ventricular tachycardia, determined by ambulatory electrocardiographic recordings, is also quite high; it is approximately 54% in these same studies. Although still unclear, some data now suggest that ventricular arrhythmias may independently influence prognosis in patients with CHF. Future research is obviously necessary to evaluate the influence of antiarrhythmic therapy on survival. However, preliminary findings appear to indicate that treatment may not affect long-term survival in these patients.
G S Francis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  57     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3B-7B     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology*
Heart / physiopathology
Heart Arrest / epidemiology
Heart Failure / complications*,  physiopathology
Heart Ventricles
Tachycardia / etiology
Time Factors
Grant Support

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