| Development and application of acute exposure guideline levels (AEGLs) for chemical warfare nerve and sulfur mustard agents. | |
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MedLine Citation:
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PMID: 16621779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute exposure guideline levels (AEGLs) have been developed for the chemical warfare agents GB, GA, GD, GF, VX, and sulfur mustard. These AEGLs were approved by the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances after Federal Register publication and comment, and judged as scientifically valid by the National Research Council Committee on Toxicology Subcommittee on AEGLs. AEGLs represent general public exposure limits for durations ranging from 10 min to 8 h, and for three levels of severity (AEGL-1, AEGL-2, AEGL-3). Mild effects are possible at concentrations greater than AEGL-1, while life-threatening effects are expected at concentrations greater than AEGL-3. AEGLs can be applied to various civilian and national defense purposes, including evacuation and shelter-in-place protocols, reentry levels, protective clothing specifications, and analytical monitoring requirements. This report documents development and derivation of AEGL values for six key chemical warfare agents, and makes recommendations for their application to various potential exposure scenarios. |
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Authors:
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Annetta Watson; Dennis Opresko; Robert Young; Veronique Hauschild |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part B, Critical reviews Volume: 9 ISSN: 1521-6950 ISO Abbreviation: J Toxicol Environ Health B Crit Rev Publication Date: 2006 May-Jun |
Date Detail:
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Created Date: 2006-04-19 Completed Date: 2006-06-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9802627 Medline TA: J Toxicol Environ Health B Crit Rev Country: United States |
Other Details:
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Languages: eng Pagination: 173-263 Citation Subset: IM |
Affiliation:
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Toxicology and Hazard Assessment Group, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830-6480, USA. watsonap@ornl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemical Warfare Agents
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poisoning* Environmental Exposure* Guidelines as Topic* Humans Reference Values Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Chemical Warfare Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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