| Development of an antithrombogenic cardiac wall substitute which can be reconstructed by infiltration of host cells. | |
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MedLine Citation:
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PMID: 3196559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various kinds of materials, such as glutaraldehyde-treated pericardial heterografts, have been used as a cardiac wall substitute. Some problems were encountered with their use. We clarified these problems in animal experiments and developed a new cardiac wall substitute to overcome them. As one of the best cardiac wall substitutes obtainable at present, glutaraldehyde-treated equine pericardium (Xenomedica, GA-graft), was sutured as a patch in the right ventricular outflow tract (Group 1: 16 dogs). A new cardiac wall substitute, which is composed of collagen-coated polyester mesh (CUFP), was sutured in the same fashion (Group 2: 19 dogs). The problems clarified in the GA graft were insufficient antithrombogenicity and poor healing of the neointima and the graft wall. The CUFP had sufficient antithrombogenicity and good healing quality as a cardiac wall substitute. CUFP should be rapidly infiltrated by host cells, to become a kind of host organ and therefore not degenerate with long-term use. |
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Authors:
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T Okoshi; Y Noishiki; Y Tomizawa; M Morishima; H Koyanagi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: ASAIO transactions / American Society for Artificial Internal Organs Volume: 34 ISSN: 0889-7190 ISO Abbreviation: ASAIO Trans Publication Date: 1988 Jul-Sep |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8611947 Medline TA: ASAIO Trans Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 532-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Okayama University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bioprosthesis* Dogs Heart Ventricles / surgery* Pericardium / cytology* Polyesters Prostheses and Implants* Prosthesis Design Surgical Mesh* Thrombosis / pathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Polyesters |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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