Document Detail

Development of antibody-forming cells in follicles of lymph nodes of mice after continuous antigenic stimulation.
MedLine Citation:
PMID:  1800313     Owner:  NLM     Status:  MEDLINE    
It was the purpose of the present study to test a hypothesis on the direct differentiation of newly formed memory B cells into antibody-forming cells (AFC) in the follicles of lymph nodes. AFC may develop in follicles when mobile antigen is present at the moment that such memory B cells have completed their differentiation under influence of immune complexes trapped on follicular dendritic cells (FDC). In order to study whether the simultaneous presence of mobile antigen and immobilized immune complexes on FDC alters the normal distribution of AFC in lymph nodes, different immunization protocols with the thymus-dependent antigens trinitrophenylated keyhole limpet haemocyanin (TNP-KLH) and horseradish peroxidase (HRP) were used. Results confirm that, provided that mobile antigen and immobilized immune complexes are present simultaneously, AFC that are normally found in the medulla of the lymph node may also develop in the follicles.
F G Delemarre; N Kors; N van Rooijen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunobiology     Volume:  184     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-04-20     Completed Date:  1992-04-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Department of Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands.
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MeSH Terms
Antibody-Producing Cells / immunology*
Antigens / immunology*
B-Lymphocytes / immunology
Cell Differentiation
Hemocyanin / immunology*
Horseradish Peroxidase
Immunoenzyme Techniques
Lymph Nodes / cytology,  immunology*
Mice, Inbred C57BL
Reg. No./Substance:
0/Antigens; 0/trinitrophenyl keyhole limpet hemocyanin; 9013-72-3/Hemocyanin; EC 1.11.1.-/Horseradish Peroxidase

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