Document Detail

Development of animal model for calcified chronic total occlusion.
MedLine Citation:
PMID:  19360862     Owner:  NLM     Status:  MEDLINE    
Chronic total coronary occlusion (CTO) remains a major problem for percutaneous revascularization, with relatively low primary success rates and a high incidence of restenosis and reocclusion compared with those of subtotal stenoses. No reproducible animal model simulating human CTOs has previously been developed. We hypothesized that an apatite-coated bioabsorbable polymer sponge could be implanted to produce calcified CTO lesions in animal coronary arteries/peripheral arteries. A total of 10 swine and six rabbits were used for this study. The apatite-coated bioabsorbable polymer sponges were implanted into a preselected segment of coronary and peripheral arteries. Four weeks after implantation, both angiography and histopathology were performed to document the presence or absence of CTO lesions. We could reproducibly develop CTO lesions in animal coronary/peripheral arteries that mimic human CTO lesions. These lesions were found to have microvascular channels and microcalcification similar to those of human older CTO lesions and demonstrate the development of adventitial arterioles, a consistent finding in human CTO. This CTO model might provide a platform for evaluating future CTO technologies as well as contributing to a better understanding of CTOs in both educational and practical terms.
Yoriyasu Suzuki; Ayako Oyane; Fumiaki Ikeno; Jennifer K Lyons; Alan C Yeung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-19     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-75     Citation Subset:  IM    
Copyright Information:
2009 Wiley-Liss, Inc.
Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305-2200, USA.
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MeSH Terms
Arterial Occlusive Diseases / etiology*,  pathology,  radiography
Calcinosis / etiology*,  pathology,  radiography
Chronic Disease
Coated Materials, Biocompatible*
Coronary Angiography
Coronary Occlusion / etiology*,  pathology,  radiography
Disease Models, Animal*
Lactic Acid / chemistry
Polyesters / chemistry
Polyglycolic Acid / chemistry
Reproducibility of Results
Surface Properties
Time Factors
Reg. No./Substance:
0/Apatites; 0/Coated Materials, Biocompatible; 0/Polyesters; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 26969-66-4/poly(lactide); 50-21-5/Lactic Acid

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