Document Detail


Development and androgen regulation of the secretory cell types of the Syrian hamster (Mesocricetus auratus) Harderian gland.
MedLine Citation:
PMID:  8242705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The secretory cell types of the hamster Harderian glands were studied in both male and female Syrian hamsters. As previously demonstrated, female hamsters showed a single secretory cell type (type I), while male hamsters displayed two secretory cell types (type I and type II). Type-II cells were observed after the first month of age correlating with the increase in testosterone levels. The administration of testosterone to adult female hamsters resulted in a marked increase in the percentage of type-II cells without a significant increase in the number of mitotic figures. Very low levels of serum testosterone were able to maintain the percentage of type-II cells. Castration of male hamsters produced a decrease in the percentage of type-II cells. This drop correlated with the reduction in serum testosterone levels. The chronic administration of a luteinizing hormone-releasing hormone agonist to male Syrian hamsters induced a significant reduction in both serum luteinizing hormone and testosterone. However, the percentage of type-II cells was similar to that of control hamsters suggesting that very low levels of circulating testosterone are able to maintain the percentage of type-II cells. In a final experiment male Syrian hamsters were treated with the antiandrogen cyproterone acetate. No changes were observed in the percentage of type-II cells, whereas serum luteinizing hormone and testosterone levels were significantly modified. We concluded that (1) type-II cells differentiate from type-I cells; (2) gonadal androgens are the major factor controlling this differentiation; and (3) the disappearance of type-II cells after androgen deprivation occurs through holocrine and apocrine mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M J Rodríguez-Colunga; C Rodríguez; I Antolín; H Uría; D Tolivia; M K Vaughan; A Menéndez-Peláez
Related Documents :
2342495 - Sce induction and cell-cycle delay by toxaphene.
7325155 - Functional deficiency of fibroblasts heterozygous for bloom syndrome as specific manife...
3457205 - Spontaneous immortalization rate of cultured chinese hamster cells.
25153355 - The multifaceted role of the embryonic gene cripto-1 in cancer, stem cells and epitheli...
7511895 - [d-arg1, d-phe5, d-trp7,9, leu11] substance p induces apoptosis in lung cancer cell lin...
3462415 - Biologic properties of cell lines derived from canine mammary carcinomas.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  274     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-29     Completed Date:  1993-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Affiliation:
Departamento de Morfología y Biología Celular, Universidad de Oviedo, Principado de Asturias, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Androgens / physiology*
Animals
Cell Differentiation / drug effects,  physiology
Cricetinae
Female
Harderian Gland / cytology,  growth & development*,  secretion
Luteinizing Hormone / physiology
Male
Mesocricetus / anatomy & histology,  growth & development*,  physiology
Orchiectomy
Receptors, Androgen / physiology
Sex Characteristics
Testis / physiology
Testosterone / pharmacology,  physiology
Chemical
Reg. No./Substance:
0/Androgens; 0/Receptors, Androgen; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: evidence for di...
Next Document:  Mouse adrenal chromaffin cells can transform to neuron-like cholinergic phenotypes after being graft...