| Development and androgen regulation of the secretory cell types of the Syrian hamster (Mesocricetus auratus) Harderian gland. | |
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MedLine Citation:
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PMID: 8242705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The secretory cell types of the hamster Harderian glands were studied in both male and female Syrian hamsters. As previously demonstrated, female hamsters showed a single secretory cell type (type I), while male hamsters displayed two secretory cell types (type I and type II). Type-II cells were observed after the first month of age correlating with the increase in testosterone levels. The administration of testosterone to adult female hamsters resulted in a marked increase in the percentage of type-II cells without a significant increase in the number of mitotic figures. Very low levels of serum testosterone were able to maintain the percentage of type-II cells. Castration of male hamsters produced a decrease in the percentage of type-II cells. This drop correlated with the reduction in serum testosterone levels. The chronic administration of a luteinizing hormone-releasing hormone agonist to male Syrian hamsters induced a significant reduction in both serum luteinizing hormone and testosterone. However, the percentage of type-II cells was similar to that of control hamsters suggesting that very low levels of circulating testosterone are able to maintain the percentage of type-II cells. In a final experiment male Syrian hamsters were treated with the antiandrogen cyproterone acetate. No changes were observed in the percentage of type-II cells, whereas serum luteinizing hormone and testosterone levels were significantly modified. We concluded that (1) type-II cells differentiate from type-I cells; (2) gonadal androgens are the major factor controlling this differentiation; and (3) the disappearance of type-II cells after androgen deprivation occurs through holocrine and apocrine mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M J Rodríguez-Colunga; C Rodríguez; I Antolín; H Uría; D Tolivia; M K Vaughan; A Menéndez-Peláez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell and tissue research Volume: 274 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-29 Completed Date: 1993-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 189-97 Citation Subset: IM |
Affiliation:
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Departamento de Morfología y Biología Celular, Universidad de Oviedo, Principado de Asturias, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgens
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physiology* Animals Cell Differentiation / drug effects, physiology Cricetinae Female Harderian Gland / cytology, growth & development*, secretion Luteinizing Hormone / physiology Male Mesocricetus / anatomy & histology, growth & development*, physiology Orchiectomy Receptors, Androgen / physiology Sex Characteristics Testis / physiology Testosterone / pharmacology, physiology |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Receptors, Androgen; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone |
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