Document Detail

Development and androgen regulation of the secretory cell types of the Syrian hamster (Mesocricetus auratus) Harderian gland.
MedLine Citation:
PMID:  8242705     Owner:  NLM     Status:  MEDLINE    
The secretory cell types of the hamster Harderian glands were studied in both male and female Syrian hamsters. As previously demonstrated, female hamsters showed a single secretory cell type (type I), while male hamsters displayed two secretory cell types (type I and type II). Type-II cells were observed after the first month of age correlating with the increase in testosterone levels. The administration of testosterone to adult female hamsters resulted in a marked increase in the percentage of type-II cells without a significant increase in the number of mitotic figures. Very low levels of serum testosterone were able to maintain the percentage of type-II cells. Castration of male hamsters produced a decrease in the percentage of type-II cells. This drop correlated with the reduction in serum testosterone levels. The chronic administration of a luteinizing hormone-releasing hormone agonist to male Syrian hamsters induced a significant reduction in both serum luteinizing hormone and testosterone. However, the percentage of type-II cells was similar to that of control hamsters suggesting that very low levels of circulating testosterone are able to maintain the percentage of type-II cells. In a final experiment male Syrian hamsters were treated with the antiandrogen cyproterone acetate. No changes were observed in the percentage of type-II cells, whereas serum luteinizing hormone and testosterone levels were significantly modified. We concluded that (1) type-II cells differentiate from type-I cells; (2) gonadal androgens are the major factor controlling this differentiation; and (3) the disappearance of type-II cells after androgen deprivation occurs through holocrine and apocrine mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)
M J Rodríguez-Colunga; C Rodríguez; I Antolín; H Uría; D Tolivia; M K Vaughan; A Menéndez-Peláez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  274     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-29     Completed Date:  1993-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Departamento de Morfología y Biología Celular, Universidad de Oviedo, Principado de Asturias, Spain.
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MeSH Terms
Androgens / physiology*
Cell Differentiation / drug effects,  physiology
Harderian Gland / cytology,  growth & development*,  secretion
Luteinizing Hormone / physiology
Mesocricetus / anatomy & histology,  growth & development*,  physiology
Receptors, Androgen / physiology
Sex Characteristics
Testis / physiology
Testosterone / pharmacology,  physiology
Reg. No./Substance:
0/Androgens; 0/Receptors, Androgen; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone

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