| Development of adenovirus capsid proteins for targeted therapeutic delivery. | |
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MedLine Citation:
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PMID: 23343164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. These stages include initial cell-surface binding followed by receptor-mediated endocytosis, endosomal penetration and cytosolic entry, and intracellular trafficking toward the nucleus. Numerous studies have shown that the penton base contributes to several of these steps and have supported the development of this protein into a delivery agent for therapeutic molecules. Studies revealing that the fiber and hexon bear unexpected properties of cell entry and/or nuclear homing have supported the development of these capsid proteins, as well into potential delivery vehicles. This review summarizes the findings to date of the protein-cell activities of these capsid proteins in the absence of the whole virus and their potential for therapeutic application with regard to the delivery of foreign molecules. |
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Authors:
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Lali K Medina-Kauwe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Therapeutic delivery Volume: 4 ISSN: 2041-5990 ISO Abbreviation: Ther Deliv Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-24 Completed Date: 2013-03-07 Revised Date: 2013-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101538870 Medline TA: Ther Deliv Country: England |
Other Details:
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Languages: eng Pagination: 267-77 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Cedars-Sinai Medical Center, Geffen School of Medicine, University of California Los Angeles, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. medinal@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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chemistry Animals Capsid Proteins / chemistry* Drug Delivery Systems* Gene Transfer Techniques* Humans |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA102126/CA/NCI NIH HHS; R01 CA129822/CA/NCI NIH HHS; R01 CA140995/CA/NCI NIH HHS; R01CA102126/CA/NCI NIH HHS; R01CA129882/CA/NCI NIH HHS; R01CA140995/CA/NCI NIH HHS; R21 CA116014/CA/NCI NIH HHS; R21 CA116014/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Capsid Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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