Document Detail


Development of adenovirus capsid proteins for targeted therapeutic delivery.
MedLine Citation:
PMID:  23343164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. These stages include initial cell-surface binding followed by receptor-mediated endocytosis, endosomal penetration and cytosolic entry, and intracellular trafficking toward the nucleus. Numerous studies have shown that the penton base contributes to several of these steps and have supported the development of this protein into a delivery agent for therapeutic molecules. Studies revealing that the fiber and hexon bear unexpected properties of cell entry and/or nuclear homing have supported the development of these capsid proteins, as well into potential delivery vehicles. This review summarizes the findings to date of the protein-cell activities of these capsid proteins in the absence of the whole virus and their potential for therapeutic application with regard to the delivery of foreign molecules.
Authors:
Lali K Medina-Kauwe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Therapeutic delivery     Volume:  4     ISSN:  2041-5990     ISO Abbreviation:  Ther Deliv     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-03-07     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101538870     Medline TA:  Ther Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae / chemistry
Animals
Capsid Proteins / chemistry*
Drug Delivery Systems*
Gene Transfer Techniques*
Humans
Grant Support
ID/Acronym/Agency:
R01 CA102126/CA/NCI NIH HHS; R01 CA129822/CA/NCI NIH HHS; R01 CA140995/CA/NCI NIH HHS; R01CA102126/CA/NCI NIH HHS; R01CA129882/CA/NCI NIH HHS; R01CA140995/CA/NCI NIH HHS; R21 CA116014/CA/NCI NIH HHS; R21 CA116014/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Capsid Proteins
Comments/Corrections

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