| Development of an acid challenge-based in vitro dentin disc occlusion model. | |
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MedLine Citation:
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PMID: 20669813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to evaluate the utility of a novel acid challenge-based dentin disc occlusion model, and to compare the occluding effect and acid resistance exhibited by currently marketed occlusion dentifrices in vitro. METHODS: Ninety-six bovine dentin discs were polished and etched in citric acid (6% w/w) for two minutes to provide a smooth dentin surface with patent tubules. The discs were divided into three treatment groups. Each treatment group was brushed (Oral-B Vitality Precision Clean/EB 17 FlexiSoft head) twice a day, for up to four days, with either a strontium acetate dentifrice (Sensodyne Rapid Relief), an arginine-based dentifrice (Colgate Sensitive Pro-Relief), or water. Prior to and between treatments, the dentin samples were stored in human saliva. On days 3 and 4, following dentifrice treatment and incubation in saliva (60 minutes), the samples were subjected to a grapefruit juice challenge. Eight samples from each treatment group were removed from the study on each day and analyzed by scanning electron microscopy (SEM). The SEM images were graded according to a categorical occlusion scale, and the data were analyzed by ANOVA. RESULTS: The strontium acetate dentifrice occluded dentin tubules significantly better than the negative control (water) on days 1 through 4 (day 4 p < or = 0.0001). The marketed occlusion-based dentifrices demonstrated various degrees of dentin tubule occlusion over the four days. The strontium acetate dentifrice demonstrated significantly better occlusion than a currently marketed arginine-based occlusion dentifrice on day 1 (p = 0.0337), day 2 (p = 0.0021 ), and day 4 (p < or = 0.0001). CONCLUSION: An in vitro model has been developed that can differentiate the dentin tubular occlusive effects of currently marketed occlusion dentifrices. Surface analysis reveals that the occluding deposits vary according to product, and that some are more susceptible to acid mediated dissolution. |
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Authors:
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Charles R Parkinson; Andrew Butler; Richard J Willson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical dentistry Volume: 21 ISSN: 0895-8831 ISO Abbreviation: J Clin Dent Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904411 Medline TA: J Clin Dent Country: United States |
Other Details:
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Languages: eng Pagination: 31-6 Citation Subset: D |
Affiliation:
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GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey, UK. charles.x.parkinson@gsk.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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therapeutic use Acid Etching, Dental Animals Arginine / therapeutic use Beverages Cattle Citric Acid / administration & dosage Citrus paradisi Dentifrices / therapeutic use* Dentin / drug effects*, ultrastructure Dentin Desensitizing Agents / therapeutic use* Dentin Sensitivity / drug therapy*, pathology Dentin Solubility / drug effects Humans Materials Testing Microscopy, Electron, Scanning Random Allocation Saliva / physiology Strontium / therapeutic use Time Factors Toothbrushing / instrumentation |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Dentifrices; 0/Dentin Desensitizing Agents; 543-94-2/strontium acetate; 74-79-3/Arginine; 7440-24-6/Strontium; 77-92-9/Citric Acid |
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