| Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. | |
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MedLine Citation:
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PMID: 19240944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ecteinascidins are marine natural products consisting of two or three linked tetrahydroisoquinoline subunits and an active carbinolamine functional group. Their potent antiproliferative activity against a variety of tumor cells makes them attractive candidates for development as anticancer agents. The lead compound, Yondelis (trabectedin, ET-743) is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Positive results of a large randomized Phase III clinical trial in ovarian cancer have recently been presented. The low amounts present in its natural source, the tunicate Ecteinascidia turbinata, made it necessary to develop efficient synthetic procedures. The original total synthesis is reviewed as well as a new semisythetic process from the readily available cynosafracin B, which has solved the supply problem. |
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Authors:
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Carmen Cuevas; Andrés Francesch |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-01-07 |
Journal Detail:
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Title: Natural product reports Volume: 26 ISSN: 0265-0568 ISO Abbreviation: Nat Prod Rep Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-25 Completed Date: 2009-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502408 Medline TA: Nat Prod Rep Country: England |
Other Details:
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Languages: eng Pagination: 322-37 Citation Subset: IM |
Affiliation:
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PharmaMar, S. A., Avenida de los Reyes, 1, 28770, Colmenar Viejo, Madrid, Spain. ccuevas@pharmamar.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Alkylating / chemical synthesis*, chemistry, pharmacology* Dioxoles / chemical synthesis*, chemistry, pharmacology* Female Humans Molecular Structure Ovarian Neoplasms / drug therapy* Randomized Controlled Trials as Topic Tetrahydroisoquinolines / chemical synthesis*, chemistry, pharmacology* Urochordata / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Dioxoles; 0/Tetrahydroisoquinolines; 114899-77-3/trabectedin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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