Document Detail


Development of an updated phytoestrogen database for use with the SWAN food frequency questionnaire: intakes and food sources in a community-based, multiethnic cohort study.
MedLine Citation:
PMID:  22211850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phytoestrogens, heterocyclic phenols found in plants, may benefit several health outcomes. However, epidemiologic studies of the health effects of dietary phytoestrogens have yielded mixed results, in part due to challenges inherent in estimating dietary intakes. The goal of this study was to improve the estimates of dietary phytoestrogen consumption using a modified Block Food Frequency Questionnaire (FFQ), a 137-item FFQ created for the Study of Women's Health Across the Nation (SWAN) in 1994. To expand the database of sources from which phytonutrient intakes were computed, we conducted a comprehensive PubMed/Medline search covering January 1994 through September 2008. The expanded database included 4 isoflavones, coumestrol, and 4 lignans. The new database estimated isoflavone content of 105 food items (76.6%) vs. 14 (10.2%) in the 1994 version and computed coumestrol content of 52 food items (38.0%), compared to 1 (0.7%) in the original version. Newly added were lignans; values for 104 FFQ food items (75.9%) were calculated. In addition, we report here the phytonutrient intakes for each racial and language group in the SWAN sample and present major food sources from which the phytonutrients came. This enhanced ascertainment of phytoestrogens will permit improved studies of their health effects.
Authors:
Mei-Hua Huang; Jean Norris; Weijuan Han; Torin Block; Ellen Gold; Sybil Crawford; Gail A Greendale
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-02
Journal Detail:
Title:  Nutrition and cancer     Volume:  64     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-06-15     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Coumestrol / administration & dosage,  analysis
Databases, Factual*
Diet / ethnology*
Female
Food*
Food Analysis
Humans
Isoflavones / administration & dosage,  analysis
Lignans / administration & dosage,  analysis
Longitudinal Studies
MEDLINE
Middle Aged
Phytoestrogens / administration & dosage,  analysis*
Questionnaires*
Residence Characteristics
United States
Women's Health
Grant Support
ID/Acronym/Agency:
AG012495/AG/NIA NIH HHS; AG012505/AG/NIA NIH HHS; AG012531/AG/NIA NIH HHS; AG012535/AG/NIA NIH HHS; AG012539/AG/NIA NIH HHS; AG012546/AG/NIA NIH HHS; AG012553/AG/NIA NIH HHS; AG012554/AG/NIA NIH HHS; AG017719/AG/NIA NIH HHS; NR004061/NR/NINR NIH HHS; R01 AG030448/AG/NIA NIH HHS; U01 AG017719/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Isoflavones; 0/Lignans; 0/Phytoestrogens; V7NW98OB34/Coumestrol
Comments/Corrections

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