| Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. | |
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MedLine Citation:
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PMID: 8097338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naïve, ovalbumin-specific alpha beta T cell receptor transgenic T cell, it was found that heat-killed Listeria monocytogenes induced TH1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may explain the ability of IL-10 to suppress TH1 development. Murine immune responses to L. monocytogenes in vivo are of the appropriate TH1 phenotype. Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype. |
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Authors:
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C S Hsieh; S E Macatonia; C S Tripp; S F Wolf; A O'Garra; K M Murphy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 260 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-14 Completed Date: 1993-05-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD4-Positive T-Lymphocytes / cytology, immunology* Cell Differentiation Cells, Cultured Interferon-gamma / secretion Interleukin-10 / pharmacology Interleukin-12 Interleukin-2 / biosynthesis Interleukins / biosynthesis, immunology*, pharmacology Listeria monocytogenes / immunology* Macrophages / immunology* Mice Mice, Transgenic Phenotype Receptors, Antigen, T-Cell, alpha-beta / immunology |
| Grant Support | |
ID/Acronym/Agency:
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1 PO1 A131238-01//PHS HHS; 5 T32 GM07200-17/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2; 0/Interleukins; 0/Receptors, Antigen, T-Cell, alpha-beta; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
Comment In:
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Science. 1993 Apr 23;260(5107):496-7
[PMID:
8097337
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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