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Development of Smooth Pursuit Eye Movements in very preterm born infants: 3. Association with perinatal risk factors.
MedLine Citation:
PMID:  21883450     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To investigate the association between perinatal risk factors and neonatal complications and early oculo-motor development in very preterm infants. Methods:  Perinatal risk factors were identified and the potential association with early oculo-motor development was evaluated by measuring smooth pursuit eye movements (SP) at 2 and 4 months' corrected age (CA) in a population of very preterm infants born in Uppsala County 2004-2007 (n=113). Results:  Among the 15 tested factors, 8 showed significant association in univariate analysis with lower levels of SP at 4 months' CA namely administration of prenatal corticosteroids, gestational age, birth weight, bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular haemorrhage > grade 2, and persistent ductus arteriosus. At 2 months' CA only retinopathy of prematurity > stage 2 was associated with lower levels of SP. When all factors significant in the univariate tests were included in multiple regressions aimed to assess each factor's independent relation to SP, periventricular leukomalacia was the only significant independent factor. When adding 2-5 of the significant factors using multiple regression analysis the levels of SP became lower. Conclusion:  Perinatal risk factors were associated with lower levels of SP. This could be interpreted as delayed or disturbed development of normal oculomotor ability.
Authors:
Katarina Strand Brodd; Helena Grönqvist; Gerd Holmström; Erik Grönqvist; Kerstin Rosander; Uwe Ewald
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Affiliation:
Departments of Women's and Children's Health Psychology Neuroscience Institute for Labour Market Policy Evaluation (IFAU) and Department of Economics, Uppsala university, Sweden.
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