| Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. | |
| | |
MedLine Citation:
|
PMID: 18803317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The myelinating and nonmyelinating Schwann cells in peripheral nerves are derived from the neural crest, which is a transient and multipotent embryonic structure that also generates the other main glial subtypes of the peripheral nervous system (PNS). Schwann cell development occurs through a series of transitional embryonic and postnatal phases, which are tightly regulated by a number of signals. During the early embryonic phases, neural crest cells are specified to give rise to Schwann cell precursors, which represent the first transitional stage in the Schwann cell lineage, and these then generate the immature Schwann cells. At birth, the immature Schwann cells differentiate into either the myelinating or nonmyelinating Schwann cells that populate the mature nerve trunks. In this review, we will discuss the biology of the transitional stages in embryonic and early postnatal Schwann cell development, including the phenotypic differences between them and the recently identified signaling pathways, which control their differentiation and maintenance. In addition, the role and importance of the microenvironment in which glial differentiation takes place will be discussed. |
| | |
Authors:
|
Ashwin Woodhoo; Lukas Sommer |
Related Documents
:
|
8885887 - In vitro destruction of nerve cell cultures by acanthamoeba spp.: a transmission and sc... 20566377 - Behavioral flexibility in a mouse model of developmental cerebellar purkinje cell loss. 20816827 - Species-specific control of cellular proliferation and the impact of large animal model... 19830837 - Microglial/macrophage cells in mammalian olfactory nerve fascicles. 19073897 - Characterization of putative stem cells in isolated human colonic crypt epithelial cell... 4021437 - The ferret as a model for inner ear research. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Glia Volume: 56 ISSN: 1098-1136 ISO Abbreviation: Glia Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-09-30 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8806785 Medline TA: Glia Country: United States |
Other Details:
|
Languages: eng Pagination: 1481-90 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Developmental Biology, University College London, London, United Kingdom. a.woodhoo@ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Communication / physiology Cell Differentiation / physiology Cell Lineage / physiology* Humans Nerve Fibers, Myelinated / metabolism*, ultrastructure Neural Crest / cytology, embryology* Peripheral Nervous System / cytology, embryology*, growth & development Schwann Cells / cytology, metabolism* Signal Transduction / physiology Stem Cells / cytology, metabolism |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biology and pathology of nonmyelinating Schwann cells.
Next Document: Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation.