Document Detail

Development of the Schwann cell lineage: from the neural crest to the myelinated nerve.
MedLine Citation:
PMID:  18803317     Owner:  NLM     Status:  MEDLINE    
The myelinating and nonmyelinating Schwann cells in peripheral nerves are derived from the neural crest, which is a transient and multipotent embryonic structure that also generates the other main glial subtypes of the peripheral nervous system (PNS). Schwann cell development occurs through a series of transitional embryonic and postnatal phases, which are tightly regulated by a number of signals. During the early embryonic phases, neural crest cells are specified to give rise to Schwann cell precursors, which represent the first transitional stage in the Schwann cell lineage, and these then generate the immature Schwann cells. At birth, the immature Schwann cells differentiate into either the myelinating or nonmyelinating Schwann cells that populate the mature nerve trunks. In this review, we will discuss the biology of the transitional stages in embryonic and early postnatal Schwann cell development, including the phenotypic differences between them and the recently identified signaling pathways, which control their differentiation and maintenance. In addition, the role and importance of the microenvironment in which glial differentiation takes place will be discussed.
Ashwin Woodhoo; Lukas Sommer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Glia     Volume:  56     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1481-90     Citation Subset:  IM    
Department of Anatomy and Developmental Biology, University College London, London, United Kingdom.
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MeSH Terms
Cell Communication / physiology
Cell Differentiation / physiology
Cell Lineage / physiology*
Nerve Fibers, Myelinated / metabolism*,  ultrastructure
Neural Crest / cytology,  embryology*
Peripheral Nervous System / cytology,  embryology*,  growth & development
Schwann Cells / cytology,  metabolism*
Signal Transduction / physiology
Stem Cells / cytology,  metabolism

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