Document Detail


Development of a Rat Model for Investigation of Experimental Splinted Uretero-ureterostomy, Ureteral Stenting and Stenosis.
MedLine Citation:
PMID:  23422485     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: Thirty-two male Sprague-Dawley rats were used. Group 1: Sham surgery; group 2: surgery with uretero-ureteral anastomosis and stenting. Histopathological evaluation was carried out using 5-bromo-2-deoxyuridine administration before the animals were sacrificed.
RESULTS: A total of thirty-one animals reached the final end-point. The most common surgical complications were urine extravasation and stent dislocations. Histological examination showed full regeneration of urothelium after 28 days and development of a scarring process. With stent insertion, moderate hypertrophia was seen. In contrast, the sham group had no evidence of significant scarring or stricture formations.
CONCLUSION: Our rat model allows for investigation of the wound healing processes of urothelium of the ureteral wall and the study of the application of new miniature stents as drainage and drug carriers.
Authors:
Matthias Maruschke; Wolfgang Kram; J Barbara Nebe; Brigitte Vollmar; Annette Zimpfer; Oliver W Hakenberg
Related Documents :
2987745 - The effects of neurotensin and [d-tyr11]-nt on the hyperactivity induced by intra-accum...
24490955 - Upregulation of cystathionine-beta-synthetase expression contributes to inflammatory pa...
1467845 - Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular per...
7963255 - Chemical inactivation of the nucleus tractus solitarius abolished hepatojejunal reflex ...
2150985 - Influence of age, sex and hypoxia on plasma dopamine-beta-hydroxylase activity in the rat.
15613765 - Carcinogenicity and chronic toxicity after inhalation exposure of rats and mice to n,n-...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Department of Urology, University Medical Center Rostock, Ernst-Heydemann-Str. 6, D 18057 Rostock, Germany. matthias.maruschke@med.uni-rostock.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol.
Next Document:  No Compensation in CD44 Stem Cell Marker Following BCL-2 Suppression By Antisense Oligonucleotides.