Document Detail

Development of a Rat Model for Investigation of Experimental Splinted Uretero-ureterostomy, Ureteral Stenting and Stenosis.
MedLine Citation:
PMID:  23422485     Owner:  NLM     Status:  In-Data-Review    
MATERIALS AND METHODS: Thirty-two male Sprague-Dawley rats were used. Group 1: Sham surgery; group 2: surgery with uretero-ureteral anastomosis and stenting. Histopathological evaluation was carried out using 5-bromo-2-deoxyuridine administration before the animals were sacrificed.
RESULTS: A total of thirty-one animals reached the final end-point. The most common surgical complications were urine extravasation and stent dislocations. Histological examination showed full regeneration of urothelium after 28 days and development of a scarring process. With stent insertion, moderate hypertrophia was seen. In contrast, the sham group had no evidence of significant scarring or stricture formations.
CONCLUSION: Our rat model allows for investigation of the wound healing processes of urothelium of the ureteral wall and the study of the application of new miniature stents as drainage and drug carriers.
Matthias Maruschke; Wolfgang Kram; J Barbara Nebe; Brigitte Vollmar; Annette Zimpfer; Oliver W Hakenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Department of Urology, University Medical Center Rostock, Ernst-Heydemann-Str. 6, D 18057 Rostock, Germany.
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