Document Detail

Development of radiotracers for the determination of the beta-cell mass in vivo.
MedLine Citation:
PMID:  20146667     Owner:  NLM     Status:  MEDLINE    
The changes in beta-cell mass (BCM) during the course of diabetes are not yet well characterized. A non-invasive method to measure the BCM in vivo would allow us to study the BCM during the onset and progression of the diseases caused by beta-cell dysfunction. PET and SPECT imaging are attractive approaches to determine the BCM because of their high sensitivity and the possibility to quantitatively analyze the images. Several targets and their corresponding radiotracers have been examined for their ability to determine the BCM including radiolabeled antibodies, antibody fragments, peptides and small molecules. Although some of these tracers show promising results, there is still no reliable method to determine the beta-cell mass in vivo. In this review, the targets and the corresponding radiotracers evaluated so far for the determination of the BCM in vivo in humans will be discussed.
Maarten Brom; Karolina Andrałojć; Wim J G Oyen; Otto C Boerman; Martin Gotthardt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  16     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1561-7     Citation Subset:  IM    
Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
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MeSH Terms
Islets of Langerhans / metabolism,  radionuclide imaging*
Organ Size
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
Grant Support
1R01 AG 030328-01/AG/NIA NIH HHS

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