Document Detail

The development and potential of acoustic radiation force impulse (ARFI) imaging for carotid artery plaque characterization.
MedLine Citation:
PMID:  21447606     Owner:  NLM     Status:  MEDLINE    
Stroke is the third leading cause of death and long-term disability in the USA. Currently, surgical intervention decisions in asymptomatic patients are based upon the degree of carotid artery stenosis. While there is a clear benefit of endarterectomy for patients with severe (> 70%) stenosis, in those with high/moderate (50-69%) stenosis the evidence is less clear. Evidence suggests ischemic stroke is associated less with calcified and fibrous plaques than with those containing softer tissue, especially when accompanied by a thin fibrous cap. A reliable mechanism for the identification of individuals with atherosclerotic plaques which confer the highest risk for stroke is fundamental to the selection of patients for vascular interventions. Acoustic radiation force impulse (ARFI) imaging is a new ultrasonic-based imaging method that characterizes the mechanical properties of tissue by measuring displacement resulting from the application of acoustic radiation force. These displacements provide information about the local stiffness of tissue and can differentiate between soft and hard areas. Because arterial walls, soft tissue, atheromas, and calcifications have a wide range in their stiffness properties, they represent excellent candidates for ARFI imaging. We present information from early phantom experiments and excised human limb studies to in vivo carotid artery scans and provide evidence for the ability of ARFI to provide high-quality images which highlight mechanical differences in tissue stiffness not readily apparent in matched B-mode images. This allows ARFI to identify soft from hard plaques and differentiate characteristics associated with plaque vulnerability or stability.
Jason D Allen; Katherine L Ham; Douglas M Dumont; Bantayehu Sileshi; Gregg E Trahey; Jeremy J Dahl
Related Documents :
18345326 - Live demonstration of surgery across international borders with uncompressed high-defin...
10975116 - Super-high-definition image systems for telemedicine.
12147086 - Telepathology: current status and future prospects in diagnostic histopathology.
21479546 - Synchrotron radiation phase-contrast x-ray ct imaging of acupuncture points.
23070106 - Image fusion of preprocedural cta with real-time fluoroscopy to guide proper hepatic ar...
20490046 - Video microscopy of living cells and dynamic molecular assemblies.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-29
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  16     ISSN:  1477-0377     ISO Abbreviation:  Vasc Med     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-10     Completed Date:  2011-12-13     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  302-11     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carotid Artery, Internal / ultrasonography*
Carotid Stenosis / complications,  surgery,  ultrasonography*
Disease Progression
Elasticity Imaging Techniques / instrumentation,  methods*
Patient Selection
Phantoms, Imaging
Plaque, Atherosclerotic / complications,  surgery,  ultrasonography*
Predictive Value of Tests
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke / etiology
Ultrasonics* / instrumentation
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Distribution of ankle brachial index and the risk factors of peripheral artery disease in a multi-et...
Next Document:  Arterial dysfunction and functional performance in patients with peripheral artery disease: A review...