| Development of the nephrotic syndrome during treatment of Crohn's disease with adalimumab. | |
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MedLine Citation:
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PMID: 20975576 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a patient with Crohn's disease who presented with renal insufficiency and the nephrotic syndrome after initiating therapy with adalimumab. Renal biopsy showed stages 2 to 3 membranous glomerulonephritis, and immunostaining showed glomerular deposition of immunoglobulin G and C3. The patient's serum creatinine decreased after discontinuation of adalimumab, and treatment with prednisone and mycophenolic acid reversed his proteinuria. The pathogenesis of glomerular disease induced by antitumor necrosis factor antibodies is uncertain, and the potential roles of the generation of autoantibodies, development of antiadalimumab antibodies, and the interaction of adalimumab with glomerular tumor necrosis factor are discussed. |
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Authors:
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Alok Gupta; Prashant Pendyala; Pradeep Arora; Michael D Sitrin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 45 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: e30-3 Citation Subset: IM |
Affiliation:
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*Division of Gastroenterology, Hepatology, and Nutrition †Division of Nephrology, Department of Medicine, University at Buffalo, State University of New York and VA Western New York Medical Center, Buffalo, New York, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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