Document Detail

Development of a HPTLC method for in-process purity testing of pentoxifylline.
MedLine Citation:
PMID:  15881088     Owner:  NLM     Status:  MEDLINE    
A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrospher RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (2:2:1:1 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r > or = 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.
Olivera Grozdanovic; Dusan Antic; Danica Agbaba
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of separation science     Volume:  28     ISSN:  1615-9306     ISO Abbreviation:  J Sep Sci     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101088554     Medline TA:  J Sep Sci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  575-80     Citation Subset:  IM    
Institute of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, 11 000 Belgrade, POB 146, Serbia & Montenegro.
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MeSH Terms
Chromatography, High Pressure Liquid / instrumentation,  methods*
Molecular Structure
Pentoxifylline / analysis*,  isolation & purification
Reproducibility of Results
Vasodilator Agents / analysis*,  isolation & purification
Reg. No./Substance:
0/Vasodilator Agents; 6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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