Document Detail


Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway.
MedLine Citation:
PMID:  21382366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper we have investigated the developmental-genetic steps that shape the entero-endocrine system of Drosophila melanogaster from the embryo to the adult. The process starts in the endoderm of the early embryo where precursors of endocrine cells and enterocytes of the larval midgut, as well as progenitors of the adult midgut, are specified by a Notch signaling-dependent mechanism. In a second step that occurs during the late larval period, enterocytes and endocrine cells of a transient pupal midgut are selected from within the clusters of adult midgut progenitors. As in the embryo, activation of the Notch pathway triggers enterocyte differentiation and inhibits cells from further proliferation or choosing the endocrine fate. The third step of entero-endocrine cell development takes place at a mid-pupal stage. Before this time point, the epithelial layer destined to become the adult midgut is devoid of endocrine cells. However, precursors of the intestinal midgut stem cells (pISCs) are already present. After an initial phase of symmetric divisions which causes an increase in their own population size, pISCs start to spin off cells that become postmitotic and express the endocrine fate marker, Prospero. Activation of Notch in pISCs forces these cells into an enterocyte fate. Loss of Notch function causes an increase in the proliferatory activity of pISCs, as well as a higher ratio of Prospero-positive cells.
Authors:
Shigeo Takashima; Katrina L Adams; Paola A Ortiz; Chong T Ying; Rameen Moridzadeh; Amelia Younossi-Hartenstein; Volker Hartenstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-05
Journal Detail:
Title:  Developmental biology     Volume:  353     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-25     Completed Date:  2011-07-01     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-72     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cell Differentiation
Cell Lineage
Cell Proliferation
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster / embryology,  growth & development*,  metabolism*
Endocrine System / embryology,  growth & development,  metabolism
Enteric Nervous System / embryology,  growth & development,  metabolism
Enterocytes / cytology,  metabolism
Female
Intestines / embryology,  growth & development,  metabolism
Intracellular Signaling Peptides and Proteins
Male
Membrane Proteins / genetics,  metabolism
Models, Biological
Morphogenesis
Neurogenesis
Receptors, Notch / genetics,  metabolism*
Recombinant Fusion Proteins / genetics,  metabolism
Signal Transduction
Grant Support
ID/Acronym/Agency:
1 R01 GM087373/GM/NIGMS NIH HHS; R01 GM087373/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Notch; 0/Recombinant Fusion Proteins; 0/delta protein; 0/escargot protein, Drosophila; 0/notch protein, Drosophila
Comments/Corrections

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