Document Detail

Development, characterization and permeability assessment based on caco-2 monolayers of self-microemulsifying floating tablets of tetrahydrocurcumin.
MedLine Citation:
PMID:  23319299     Owner:  NLM     Status:  MEDLINE    
Novel self-microemulsifying floating tablets were developed to enhance the dissolution and oral absorption of the poorly water-soluble tetrahydrocurcumin (THC). Their physicochemical properties and THC permeability across Caco-2 cell monolayers were assessed. The self-microemulsifying liquid containing THC was adsorbed onto colloidal silicon dioxide, mixed with HPMC, gas-generating agents (sodium bicarbonate and tartaric acid), lactose and silicified-microcrystalline cellulose and transformed into tablets by direct compression. The use of different types/concentrations of HPMC and sodium bicarbonate in tablet formulations had different effects on the floating characteristics and in vitro THC release. The optimum tablet formulation (F2) provided a short floating lag time (∼23 s) together with a prolonged buoyancy (>12 h). About 72% of THC was released in 12 h with an emulsion droplet size in aqueous media of 33.9±1.0 nm while that of a self-microemulsifying liquid was 29.9±0.3 nm. The tablet formulation was stable under intermediate and accelerated storage conditions for up to 6 months. The THC released from the self-microemulsifying liquid and tablet formulations provided an approximately three- to fivefold greater permeability across the Caco-2 cell monolayers than the unformulated THC and indicated an enhanced absorption of THC by the formulations. The self-microemulsifying floating tablet could provide a dosage form with the potential to improve the oral bioavailability of THC and other hydrophobic compounds.
Namfa Sermkaew; Kamonthip Wiwattanawongsa; Wichan Ketjinda; Ruedeekorn Wiwattanapatapee
Related Documents :
1915539 - Effect of distilled water and bacillus calmette-guérin on exfoliated bladder tumor cells.
21650389 - Peer reviewed: east central europe: an environment in transition.
23831539 - Preparation and properties of nanometer silk fibroin peptide/polyvinyl alcohol blend fi...
20630289 - Evaluation and prevention of the precipitate formed on interaction between sodium hypoc...
24582219 - Electrical stimulation to promote osteogenesis using conductive polypyrrole films.
23506039 - Testosterone influences water transport in porcine granulosa cells.
9798149 - Adhesion of aeromonas hydrophila to water distribution system pipes after different con...
22233899 - Comparison of methods for the enumeration of clostridium perfringens spores in water.
19226599 - Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-15
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caco-2 Cells
Chromatography, High Pressure Liquid
Curcumin / analogs & derivatives*,  chemistry
Microscopy, Electron, Scanning
Reg. No./Substance:
0/Emulsions; 0/Tablets; 00U0645U03/tetrahydrocurcumin; IT942ZTH98/Curcumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stability enhancement of drug layered pellets in a fixed dose combination tablet.
Next Document:  Liquid proliposomes of nimodipine drug delivery system: preparation, characterization, and pharmacok...