Document Detail


Development of bilayer floating tablet of amoxicillin and Aloe vera gel powder for treatment of gastric ulcers.
MedLine Citation:
PMID:  23135966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Usual treatment for Helicobacter pylori-induced peptic ulcer includes a 'triple therapy' consisting of two antibiotics (amoxicillin and clarithromycin) and a proton pump inhibitor (omeprazole). The objective of this project work was defined with a view to retain the drug in stomach for better antiulcer activity and substituting one of the synthetic drugs in this therapy with a herbal alternative. Hence, aim of the present work was to design and develop a bilayer floating tablet of amoxicillin and Aloe vera gel powder for the treatment of peptic ulcer. A. vera gel powder is used for its cytoprotective action. Bilayer floating tablets were prepared by applying direct compression technique. The proportion of sodium bicarbonate and citric acid was adjusted to get the least possible lag time with good matrix integrity and total floating time. Polymer concentration was adjusted to get the maximum release in 8 h. The formulation was developed using hydroxypropyl methyl cellulose (HPMC) K4M and HPMC K100M in a ratio of 85:15 along with 1:4 ratio of effervescent agents was found to give floating lag time of less than 1 min with total floating time of more than 8 h and 97.0% drug release in 8 h. In vivo study in rats meets the requirement of antiulcer activity for bilayer tablet in comparison to single amoxicillin as standard.
Authors:
Arati N Ranade; Sonali S Wankhede; Nisharani S Ranpise; Mayur S Mundada
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Publication Detail:
Type:  Journal Article     Date:  2012-11-08
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  13     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-15     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1518-23     Citation Subset:  IM    
Affiliation:
STES's Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune, 411041, Maharashtra, India. aratiranade@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Aloe / chemistry*
Amoxicillin / chemistry*,  pharmacology
Animals
Chemistry, Pharmaceutical / methods
Citric Acid / chemistry
Drug Compounding / methods
Gels / chemistry*,  pharmacology
Male
Methylcellulose / analogs & derivatives,  chemistry
Polymers / chemistry
Powders / chemistry*,  pharmacology
Rats
Rats, Wistar
Sodium Bicarbonate / chemistry
Stomach Ulcer / drug therapy*
Tablets / chemistry*,  pharmacology
Chemical
Reg. No./Substance:
0/Gels; 0/Polymers; 0/Powders; 0/Tablets; 144-55-8/Sodium Bicarbonate; 26787-78-0/Amoxicillin; 77-92-9/Citric Acid; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose
Comments/Corrections

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