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Development of (68) Ga-labeled fatty acids for their potential use in cardiac metabolic imaging.
MedLine Citation:
PMID:  24966158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
While [(11) C]palmitate continues to be a promising tracer for cardiovascular Positron Emission Tomography (PET) imaging, unfavourable logistics due to the short half-life of (11) C (20 min) and cumbersome labeling methodologies are the major impediments that limit its widespread use. In order to circumvent such limitations, an attempt has been made to explore the potential of (68) Ga-labeled fatty acid analogs for metabolic imaging owing to the availability of (68) Ga through a (68) Ge/(68) Ga generator on an on-demand basis. In this study, two fatty acid conjugates were synthesized by conjugation of p-SCN-benzyl NOTA with the ω-amino group of 11-amino undecanoic acid and 12-amino dodecanoic acid, respectively, under alkaline conditions. Both derivatives were radiolabeled in high yields with (68) Ga obtained from an in-house (68) Ge/(68) Ga generator. Biodistribution studies in Swiss mice showed reasonable myocardial uptake at 2 min for both derivatives (7.4 ± 2.8% ID/g for 11-carbon fatty acid-NOTA conjugate and 6.4 ± 2.1% ID/g for 12-carbon fatty acid-NOTA conjugate), which cleared rapidly over 30 min. However, significant activity was found in blood for both tracers, with heart/blood ratios observed to be below 0.5 at all time points, diminishing the potential of the synthesized complexes for cardiac imaging. Copyright © 2014 John Wiley & Sons, Ltd.
Authors:
Akanksha Jindal; Anupam Mathur; Usha Pandey; H D Sarma; Pradip Chaudhari; Ashutosh Dash
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of labelled compounds & radiopharmaceuticals     Volume:  57     ISSN:  1099-1344     ISO Abbreviation:  J Labelled Comp Radiopharm     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610510     Medline TA:  J Labelled Comp Radiopharm     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 John Wiley & Sons, Ltd.
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