| Development of 5'- and 7'-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase. | |
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MedLine Citation:
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PMID: 22678981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Leaving the light on: We have developed acid-tolerant luciferin analogues with pH-independent luminescence spectra as well as stable luminescence intensity in response to acidic pH change in the presence of luciferase. These compounds permitted robust bioluminescence microscopic imaging of luciferase-expressing single cells in an acidic environment typical of those encountered in many biological processes. |
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Authors:
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Hideo Takakura; Ryosuke Kojima; Takeaki Ozawa; Tetsuo Nagano; Yasuteru Urano |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-8 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: - ISSN: 1439-7633 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan). |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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