Document Detail


Development of 5'- and 7'-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase.
MedLine Citation:
PMID:  22678981     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Leaving the light on: We have developed acid-tolerant luciferin analogues with pH-independent luminescence spectra as well as stable luminescence intensity in response to acidic pH change in the presence of luciferase. These compounds permitted robust bioluminescence microscopic imaging of luciferase-expressing single cells in an acidic environment typical of those encountered in many biological processes.
Authors:
Hideo Takakura; Ryosuke Kojima; Takeaki Ozawa; Tetsuo Nagano; Yasuteru Urano
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-8
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  -     ISSN:  1439-7633     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
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