| Development of 2'-o-methyloligoribonucleotide and peptide nucleic acid based artificial ribonucleases. | |
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MedLine Citation:
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PMID: 18029656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have developed 2'-O-methyloligoribonucleotide and peptide nucleic acid (PNA) based artificial ribonucleases (OBAN's), which in presence of zinc or copper ions cleave a potential therapy target in leukemia, an M-BCR/ABL mRNA model. The OBAN's give turnover of substrate and are thus real enzymes. A copper ion based system even gives single site cleavage in the RNA-substrate. |
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Authors:
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Merita Murtola; Roger Strömberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-21 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 201-2 Citation Subset: IM |
Affiliation:
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Department of Biosciences & Nutrition, Novum, Karolinska Institutet, S-14157 Huddinge, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Copper
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chemistry Fusion Proteins, bcr-abl / genetics* Oligoribonucleotides / chemistry* Peptide Nucleic Acids / chemistry* RNA, Messenger / metabolism Ribonucleases / chemistry* Zinc / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Fusion Proteins, bcr-abl; 0/Oligoribonucleotides; 0/Peptide Nucleic Acids; 0/RNA, Messenger; 7440-50-8/Copper; 7440-66-6/Zinc; EC 3.1.-/Ribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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