Document Detail


Developing a study method for producing 400 microm spheroids.
MedLine Citation:
PMID:  12429494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to obtain 400 microm spheroids that can be sprinkled on food to improve patient compliance particularly in the case of children and old people. A methodology to select wet masses for extrusion-spheronization through a 400 microm orifice was developed. The first step was to define the parameters that make it possible to assess the qualities required by the wet mass and the extrudates and evaluation norms: plasticity, cohesiveness, brittleness of the mass and the extrudates, and appearance of extrudates. A feasibility assay was then performed on the cylinder extruder, showing that extrusion of the lactose/Avicel PH 101/water (50/50/60) mass is not feasible through the 400 microm orifice. Precirol ato 5 and Gelucire 50/02 wetted with a sodium lauryl sulfate solution at 0.5% show plastic flow through the 400 microm diameter orifice. The presence of Avicel PH 101 does not improve plasticity for this orifice. Micropellets of 400 microm have been proved feasible as long as excipients with suitable pharmaceutical technological properties are used. After proving the feasibility of 400 microm spheroids of Gelucire 50/02, we considered the association of a drug with it.
Authors:
G Dupont; M P Flament; P Leterme; N Farah; A Gayot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  247     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V.
Affiliation:
Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacotechnie Industrielle, BP 83 Rue du Professeur Laguesse, Lille 59006, France.
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MeSH Terms
Descriptor/Qualifier:
Cellulose / administration & dosage,  chemistry
Microspheres
Nanotechnology / methods*
Technology, Pharmaceutical / methods*
Chemical
Reg. No./Substance:
9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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