| Developing new metal-based therapeutics: challenges and opportunities. | |
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MedLine Citation:
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PMID: 17992277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unexpected side effects and problems experienced in clinical trials have created a difficult environment for those developing new pharmaceuticals and, as a consequence, the number of new chemical entities being registered has fallen to a historic low. Those developing metal-based therapeutics will face the same difficulties, but this environment also provides many opportunities for creative solutions to be applied to overcoming the problems and concerns. In this perspective, these challenges and opportunities are considered in the context of examples of a number of classes of metal-based therapeutics. |
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Authors:
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Trevor W Hambley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-10-04 |
Journal Detail:
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Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9226 ISO Abbreviation: Dalton Trans Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-09 Completed Date: 2008-02-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: England |
Other Details:
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Languages: eng Pagination: 4929-37 Citation Subset: IM |
Affiliation:
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Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. t.hambley@chem.usyd.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Design* Metals / therapeutic use* Models, Molecular Radioisotopes / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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