Document Detail


Developing a long-term surviving piglet model of neonatal hypoxic-ischemic encephalopathy.
MedLine Citation:
PMID:  15829153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was designed to develop a piglet model of neonatal hypoxic-ischemic encephalopathy, which would allow for serial assessments of long-term neurodevelopmental impairment. METHODS: In 12 newborn piglets, we produced hypoxia by 8% oxygen breathing for 5-91 minutes. We combined ischemia by reversible bilateral common carotid artery occlusion for varying times. Outcome measures were clinical neurological evaluation, magnetic resonance spectroscopy studies and brain histology. RESULTS: Those animals which received intravenous sedation and no mechanical ventilation showed poor tolerance to hypoxia-ischemia and died early in the course of the experiments. The use of inhalation anesthesia during surgical procedures and mechanical ventilation during hypoxia-ischemia was associated with long-term survival. Seven of eight animals that survived > or = 48 hr showed clinical neurological abnormalities, that later resolved. Magnetic resonance spectroscopy measurements did not change significantly following hypoxia-ischemia. None of the animals had histopathological brain lesions. CONCLUSION: When subjected to acute hypoxia-ischemia, piglets were likely to survive only if they were given such supportive measures as anesthesia and mechanical ventilation. Even with hypoxic-ischemic injury sufficient to produce acute signs of neurological dysfunctions, longterm, stable survival with no evident brain histopathological abnormalities was possible.
Authors:
Kristine M McCulloch; Tonse N K Raju; Shankararao Navale; C Tyler Burt; Tabasam Roohey; Anastasia Moustogiannis; James F Zachary
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological research     Volume:  27     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-04-14     Completed Date:  2005-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Illinois at Chicago, USA. jsm734@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / pathology*,  radionuclide imaging
Disease Models, Animal*
Female
Hypoxia-Ischemia, Brain* / complications,  mortality,  pathology
Infarction, Middle Cerebral Artery
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy / methods
Male
Neurologic Examination / methods
Outcome Assessment (Health Care) / methods
Phosphorus Isotopes / metabolism
Swine
Time Factors
Chemical
Reg. No./Substance:
0/Phosphorus Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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