| Developing a long-term surviving piglet model of neonatal hypoxic-ischemic encephalopathy. | |
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MedLine Citation:
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PMID: 15829153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was designed to develop a piglet model of neonatal hypoxic-ischemic encephalopathy, which would allow for serial assessments of long-term neurodevelopmental impairment. METHODS: In 12 newborn piglets, we produced hypoxia by 8% oxygen breathing for 5-91 minutes. We combined ischemia by reversible bilateral common carotid artery occlusion for varying times. Outcome measures were clinical neurological evaluation, magnetic resonance spectroscopy studies and brain histology. RESULTS: Those animals which received intravenous sedation and no mechanical ventilation showed poor tolerance to hypoxia-ischemia and died early in the course of the experiments. The use of inhalation anesthesia during surgical procedures and mechanical ventilation during hypoxia-ischemia was associated with long-term survival. Seven of eight animals that survived > or = 48 hr showed clinical neurological abnormalities, that later resolved. Magnetic resonance spectroscopy measurements did not change significantly following hypoxia-ischemia. None of the animals had histopathological brain lesions. CONCLUSION: When subjected to acute hypoxia-ischemia, piglets were likely to survive only if they were given such supportive measures as anesthesia and mechanical ventilation. Even with hypoxic-ischemic injury sufficient to produce acute signs of neurological dysfunctions, longterm, stable survival with no evident brain histopathological abnormalities was possible. |
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Authors:
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Kristine M McCulloch; Tonse N K Raju; Shankararao Navale; C Tyler Burt; Tabasam Roohey; Anastasia Moustogiannis; James F Zachary |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 27 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-04-14 Completed Date: 2005-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 16-21 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Illinois at Chicago, USA. jsm734@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Brain / pathology*, radionuclide imaging Disease Models, Animal* Female Hypoxia-Ischemia, Brain* / complications, mortality, pathology Infarction, Middle Cerebral Artery Magnetic Resonance Imaging / methods Magnetic Resonance Spectroscopy / methods Male Neurologic Examination / methods Outcome Assessment (Health Care) / methods Phosphorus Isotopes / metabolism Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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