Document Detail


Developing gelatin-starch blends for use as capsule materials.
MedLine Citation:
PMID:  23218320     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Blends of gelatin with up to 50% hydroxypropylated high amylose (80%) corn starch were developed as capsule materials. Poly(ethylene glycol) (PEG) was used as both a plasticizer and a compatibilizer in the blends. In order to prepare hard capsules for pharmaceutical applications using the well-established method of dipping stainless steel mold pins into solution, solutions with higher solids concentrations (up to 30%) were developed. The solutions, films and capsules of the different gelatin-starch blends were characterized by viscosity, transparency, tensile testing, water contact angle and SEM. The linear microstructure of the high amylose starch, and the flexible and more hydrophilic hydroxylpropylene groups grafted onto the starch improved the compatibility between the gelatin and starch. SEM revealed a continuous phase of gelatin on the surface of films from all blends. The water contact angle of pure gelatin and the different blends were similar, indicating a continuous phase of gelatin. By optimizing temperature and incubation time to control viscosity, capsules of various blends were successfully developed. PEG increased the transparency and toughness of the various blends.
Authors:
Nuozi Zhang; Hongsheng Liu; Long Yu; Xingxun Liu; Liang Zhang; Ling Chen; Robert Shanks
Publication Detail:
Type:  Journal Article     Date:  2012-10-02
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
CPFRR, ERCPSP, School of Light Industry and Food Engineering South China University of Technology, Guangzhou 510640, China; Commonwealth Scientific and Industrial Research Organisation Division of Materials Science and Engineering, Clayton, Victoria 3169, Australia; School of Applied Sciences, RMIT University, Melbourne, 3000, Australia.
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